Beneficial Effects of Epigallocatechin-3-<i>O</i>-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases
Many observational and clinical studies have shown that consumption of diets rich in plant polyphenols have beneficial effects on various diseases such as cancer, obesity, diabetes, cardiovascular diseases, and neurodegenerative diseases (NDDs). Animal and cellular studies have indicated that these...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/2/415 |
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| author | Ryuuta Fukutomi Tomokazu Ohishi Yu Koyama Monira Pervin Yoriyuki Nakamura Mamoru Isemura |
| author_facet | Ryuuta Fukutomi Tomokazu Ohishi Yu Koyama Monira Pervin Yoriyuki Nakamura Mamoru Isemura |
| author_sort | Ryuuta Fukutomi |
| collection | DOAJ |
| description | Many observational and clinical studies have shown that consumption of diets rich in plant polyphenols have beneficial effects on various diseases such as cancer, obesity, diabetes, cardiovascular diseases, and neurodegenerative diseases (NDDs). Animal and cellular studies have indicated that these polyphenolic compounds contribute to such effects. The representative polyphenols are epigallocatechin-3-<i>O</i>-gallate in tea, chlorogenic acids in coffee, resveratrol in wine, and curcumin in curry. The results of human studies have suggested the beneficial effects of consumption of these foods on NDDs including Alzheimer’s and Parkinson’s diseases, and cellular animal experiments have provided molecular basis to indicate contribution of these representative polyphenols to these effects. This article provides updated information on the effects of these foods and their polyphenols on NDDs with discussions on mechanistic aspects of their actions mainly based on the findings derived from basic experiments. |
| first_indexed | 2024-03-09T04:45:39Z |
| format | Article |
| id | doaj.art-1b2962f20c3941ce82c1356b085fa526 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:45:39Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1b2962f20c3941ce82c1356b085fa5262023-12-03T13:15:19ZengMDPI AGMolecules1420-30492021-01-0126241510.3390/molecules26020415Beneficial Effects of Epigallocatechin-3-<i>O</i>-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative DiseasesRyuuta Fukutomi0Tomokazu Ohishi1Yu Koyama2Monira Pervin3Yoriyuki Nakamura4Mamoru Isemura5Quality Management Division, Higuchi Inc. Minato-ku, Tokyo 108-0075, JapanInstitute of Microbial Chemistry (BIKAKEN), Microbial Chemistry Research Foundation, Numazu, Shizuoka 410-0301, JapanShizuoka Eiwa Gakuin University Junior College, Suruga-ku, Shizuoka 422-8545, JapanTea Science Research Center, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, JapanTea Science Research Center, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, JapanTea Science Research Center, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, JapanMany observational and clinical studies have shown that consumption of diets rich in plant polyphenols have beneficial effects on various diseases such as cancer, obesity, diabetes, cardiovascular diseases, and neurodegenerative diseases (NDDs). Animal and cellular studies have indicated that these polyphenolic compounds contribute to such effects. The representative polyphenols are epigallocatechin-3-<i>O</i>-gallate in tea, chlorogenic acids in coffee, resveratrol in wine, and curcumin in curry. The results of human studies have suggested the beneficial effects of consumption of these foods on NDDs including Alzheimer’s and Parkinson’s diseases, and cellular animal experiments have provided molecular basis to indicate contribution of these representative polyphenols to these effects. This article provides updated information on the effects of these foods and their polyphenols on NDDs with discussions on mechanistic aspects of their actions mainly based on the findings derived from basic experiments.https://www.mdpi.com/1420-3049/26/2/415polyphenolsEGCGchlorogenic acidresveratrolcurcuminNDD |
| spellingShingle | Ryuuta Fukutomi Tomokazu Ohishi Yu Koyama Monira Pervin Yoriyuki Nakamura Mamoru Isemura Beneficial Effects of Epigallocatechin-3-<i>O</i>-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases Molecules polyphenols EGCG chlorogenic acid resveratrol curcumin NDD |
| title | Beneficial Effects of Epigallocatechin-3-<i>O</i>-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases |
| title_full | Beneficial Effects of Epigallocatechin-3-<i>O</i>-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases |
| title_fullStr | Beneficial Effects of Epigallocatechin-3-<i>O</i>-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases |
| title_full_unstemmed | Beneficial Effects of Epigallocatechin-3-<i>O</i>-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases |
| title_short | Beneficial Effects of Epigallocatechin-3-<i>O</i>-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases |
| title_sort | beneficial effects of epigallocatechin 3 i o i gallate chlorogenic acid resveratrol and curcumin on neurodegenerative diseases |
| topic | polyphenols EGCG chlorogenic acid resveratrol curcumin NDD |
| url | https://www.mdpi.com/1420-3049/26/2/415 |
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