The use of a polyvalent bacterial lysate in a complex therapy of chronic urticaria
The aim of the study was to study trigger factors in chronic urticaria, peculiarities in the expression of Toll-like receptors, clinical and immunological efficacy of microbial antigens in patients with chronic urticaria.Materials and methods. Patients with chronic urticaria (134 patients). A study...
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2019-11-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
| Subjects: | |
| Online Access: | https://microbiol.elpub.ru/jour/article/view/471 |
| _version_ | 1811285285509529600 |
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| author | E. V. Sorokina N. G. Sivakova E. A. Akhmatova N. N. Mitrofanova S. A. Shodova N. K. Akhmatova |
| author_facet | E. V. Sorokina N. G. Sivakova E. A. Akhmatova N. N. Mitrofanova S. A. Shodova N. K. Akhmatova |
| author_sort | E. V. Sorokina |
| collection | DOAJ |
| description | The aim of the study was to study trigger factors in chronic urticaria, peculiarities in the expression of Toll-like receptors, clinical and immunological efficacy of microbial antigens in patients with chronic urticaria.Materials and methods. Patients with chronic urticaria (134 patients). A study of the expression of TLR2, TLR3, TLR4, TLR9 on blood cells using flow cytometry. 62 patients received polyvalent bacterial lysate against baseline therapy per os, 72 patients received monotherapy with basic drugs.Results. In patients with bacterial infection, high levels of TLR2, TLR4 expression were detected. In the presence of viral infections, high TLR3 expression values were observed. The use of PBL contributed to an increase in the number of patients with clinical remission, decreased urticaria activity, led to a correction in TLR2 and TLR4, and decreased the level of total IgE.Conclusion. Inclusion in the complex of therapeutic and prophylactic measures in patients with urticaria of a chronic drug based on microbial antigens (polyvalent bacterial lysate) contributes to the increase of clinical effectiveness and activation of the links of innate immunity. |
| first_indexed | 2024-04-13T02:41:52Z |
| format | Article |
| id | doaj.art-1b296f492a344428b28e6c926d2dd131 |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-04-13T02:41:52Z |
| publishDate | 2019-11-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-1b296f492a344428b28e6c926d2dd1312022-12-22T03:06:10ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132019-11-0105343910.36233/0372-9311-2019-5-34-39439The use of a polyvalent bacterial lysate in a complex therapy of chronic urticariaE. V. Sorokina0N. G. Sivakova1E. A. Akhmatova2N. N. Mitrofanova3S. A. Shodova4N. K. Akhmatova5Mechnikov Research Institute of Vaccines and Sera; Academy of Postgraduate Education of FMBAMechnikov Research Institute of Vaccines and SeraMechnikov Research Institute of Vaccines and SeraMedical Institute of Penza State UniversityMechnikov Research Institute of Vaccines and SeraMechnikov Research Institute of Vaccines and SeraThe aim of the study was to study trigger factors in chronic urticaria, peculiarities in the expression of Toll-like receptors, clinical and immunological efficacy of microbial antigens in patients with chronic urticaria.Materials and methods. Patients with chronic urticaria (134 patients). A study of the expression of TLR2, TLR3, TLR4, TLR9 on blood cells using flow cytometry. 62 patients received polyvalent bacterial lysate against baseline therapy per os, 72 patients received monotherapy with basic drugs.Results. In patients with bacterial infection, high levels of TLR2, TLR4 expression were detected. In the presence of viral infections, high TLR3 expression values were observed. The use of PBL contributed to an increase in the number of patients with clinical remission, decreased urticaria activity, led to a correction in TLR2 and TLR4, and decreased the level of total IgE.Conclusion. Inclusion in the complex of therapeutic and prophylactic measures in patients with urticaria of a chronic drug based on microbial antigens (polyvalent bacterial lysate) contributes to the increase of clinical effectiveness and activation of the links of innate immunity.https://microbiol.elpub.ru/jour/article/view/471chronic urticariatoll-like receptorspolyvalent bacterial lysate |
| spellingShingle | E. V. Sorokina N. G. Sivakova E. A. Akhmatova N. N. Mitrofanova S. A. Shodova N. K. Akhmatova The use of a polyvalent bacterial lysate in a complex therapy of chronic urticaria Журнал микробиологии, эпидемиологии и иммунобиологии chronic urticaria toll-like receptors polyvalent bacterial lysate |
| title | The use of a polyvalent bacterial lysate in a complex therapy of chronic urticaria |
| title_full | The use of a polyvalent bacterial lysate in a complex therapy of chronic urticaria |
| title_fullStr | The use of a polyvalent bacterial lysate in a complex therapy of chronic urticaria |
| title_full_unstemmed | The use of a polyvalent bacterial lysate in a complex therapy of chronic urticaria |
| title_short | The use of a polyvalent bacterial lysate in a complex therapy of chronic urticaria |
| title_sort | use of a polyvalent bacterial lysate in a complex therapy of chronic urticaria |
| topic | chronic urticaria toll-like receptors polyvalent bacterial lysate |
| url | https://microbiol.elpub.ru/jour/article/view/471 |
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