Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis
Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes. Unfortunately, drugs are u...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/11/1056 |
| _version_ | 1797548726885023744 |
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| author | Artur Y. Prilepskii Nikita S. Serov Daniil V. Kladko Vladimir V. Vinogradov |
| author_facet | Artur Y. Prilepskii Nikita S. Serov Daniil V. Kladko Vladimir V. Vinogradov |
| author_sort | Artur Y. Prilepskii |
| collection | DOAJ |
| description | Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes. Unfortunately, drugs are unable to effectively prevent plaque formation. Systemic administration of pharmaceuticals for the inhibition of plaque destabilization bears the risk of adverse effects. At present, nanoscience and, in particular, nanomedicine has made significant progress in both imaging and treatment of atherosclerosis. In this review, we focus on recent advances in this area, discussing subjects such as nanocarriers-based drug targeting principles, approaches towards the treatment of atherosclerosis, utilization of theranostic agents, and future prospects of nanoformulated therapeutics against atherosclerosis and inflammatory diseases. The focus is placed on articles published since 2015 with additional attention to research completed in 2019–2020. |
| first_indexed | 2024-03-10T15:04:47Z |
| format | Article |
| id | doaj.art-1b29b31147ec4620a109beb6d0092f3e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T15:04:47Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-1b29b31147ec4620a109beb6d0092f3e2023-11-20T19:52:39ZengMDPI AGPharmaceutics1999-49232020-11-011211105610.3390/pharmaceutics12111056Nanoparticle-Based Approaches towards the Treatment of AtherosclerosisArtur Y. Prilepskii0Nikita S. Serov1Daniil V. Kladko2Vladimir V. Vinogradov3International Institute “Solution Chemistry of Advanced Materials and Technologies”, ITMO University, 191002 Saint Petersburg, RussiaInternational Institute “Solution Chemistry of Advanced Materials and Technologies”, ITMO University, 191002 Saint Petersburg, RussiaInternational Institute “Solution Chemistry of Advanced Materials and Technologies”, ITMO University, 191002 Saint Petersburg, RussiaInternational Institute “Solution Chemistry of Advanced Materials and Technologies”, ITMO University, 191002 Saint Petersburg, RussiaAtherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes. Unfortunately, drugs are unable to effectively prevent plaque formation. Systemic administration of pharmaceuticals for the inhibition of plaque destabilization bears the risk of adverse effects. At present, nanoscience and, in particular, nanomedicine has made significant progress in both imaging and treatment of atherosclerosis. In this review, we focus on recent advances in this area, discussing subjects such as nanocarriers-based drug targeting principles, approaches towards the treatment of atherosclerosis, utilization of theranostic agents, and future prospects of nanoformulated therapeutics against atherosclerosis and inflammatory diseases. The focus is placed on articles published since 2015 with additional attention to research completed in 2019–2020.https://www.mdpi.com/1999-4923/12/11/1056atherosclerosisnanoparticlestarget delivery |
| spellingShingle | Artur Y. Prilepskii Nikita S. Serov Daniil V. Kladko Vladimir V. Vinogradov Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis Pharmaceutics atherosclerosis nanoparticles target delivery |
| title | Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis |
| title_full | Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis |
| title_fullStr | Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis |
| title_full_unstemmed | Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis |
| title_short | Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis |
| title_sort | nanoparticle based approaches towards the treatment of atherosclerosis |
| topic | atherosclerosis nanoparticles target delivery |
| url | https://www.mdpi.com/1999-4923/12/11/1056 |
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