Immune Subtypes Based on Immune-Related lncRNA: Differential Prognostic Mechanism of Pancreatic Cancer
Pancreatic cancer consists one of tumors with the highest degree of malignancy and the worst prognosis. To date, immunotherapy has become an effective means to improve the prognosis of patients with pancreatic cancer. Long non-coding RNAs (lncRNAs) have also been associated with the immune response....
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.698296/full |
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| author | Qiyao Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Zhihui Wang Zhihui Wang Zhihui Wang Zhihui Wang Xiao Yu Xiao Yu Xiao Yu Xiao Yu Menggang Zhang Menggang Zhang Menggang Zhang Menggang Zhang Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Yuting He Yuting He Yuting He Yuting He Wenzhi Guo Wenzhi Guo Wenzhi Guo Wenzhi Guo |
| author_facet | Qiyao Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Zhihui Wang Zhihui Wang Zhihui Wang Zhihui Wang Xiao Yu Xiao Yu Xiao Yu Xiao Yu Menggang Zhang Menggang Zhang Menggang Zhang Menggang Zhang Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Yuting He Yuting He Yuting He Yuting He Wenzhi Guo Wenzhi Guo Wenzhi Guo Wenzhi Guo |
| author_sort | Qiyao Zhang |
| collection | DOAJ |
| description | Pancreatic cancer consists one of tumors with the highest degree of malignancy and the worst prognosis. To date, immunotherapy has become an effective means to improve the prognosis of patients with pancreatic cancer. Long non-coding RNAs (lncRNAs) have also been associated with the immune response. However, the role of immune-related lncRNAs in the immune response of pancreatic cancer remains unclear. In this study, we identified immune-related lncRNA pairs through a new combinatorial algorithm, and then clustered and deeply analyzed the immune characteristics and functional differences between subtypes. Subsequently, the prognostic model of 3 candidate lncRNA pairs was determined by multivariate COX analysis. The results showed significant prognostic differences between the C1 and C2 subtypes, which may be due to the differential infiltration of CTL and NK cells and the activation of tumor-related pathways. The prognostic model of the 3 lncRNA pairs (AC244035.1_vs._AC063926.1, AC066612.1_vs._AC090124.1, and AC244035.1_vs._LINC01885) was established, which exhibits stable and effective prognostic prediction performance. These 3 lncRNA pairs may regulate the anti-tumor effect of immune cells through ion channel pathways. In conclusion, our research demonstrated the panoramic differences in immune characteristics between subtypes and stable prognostic models, and identified new potential targets for immunotherapy. |
| first_indexed | 2024-12-22T06:12:23Z |
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| id | doaj.art-1b29fb3f729d40d0ae0930cc3b49c6ab |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T06:12:23Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-1b29fb3f729d40d0ae0930cc3b49c6ab2022-12-21T18:36:11ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.698296698296Immune Subtypes Based on Immune-Related lncRNA: Differential Prognostic Mechanism of Pancreatic CancerQiyao Zhang0Qiyao Zhang1Qiyao Zhang2Qiyao Zhang3Zhihui Wang4Zhihui Wang5Zhihui Wang6Zhihui Wang7Xiao Yu8Xiao Yu9Xiao Yu10Xiao Yu11Menggang Zhang12Menggang Zhang13Menggang Zhang14Menggang Zhang15Qingyuan Zheng16Qingyuan Zheng17Qingyuan Zheng18Qingyuan Zheng19Yuting He20Yuting He21Yuting He22Yuting He23Wenzhi Guo24Wenzhi Guo25Wenzhi Guo26Wenzhi Guo27Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaOpen and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, ChinaHenan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, ChinaPancreatic cancer consists one of tumors with the highest degree of malignancy and the worst prognosis. To date, immunotherapy has become an effective means to improve the prognosis of patients with pancreatic cancer. Long non-coding RNAs (lncRNAs) have also been associated with the immune response. However, the role of immune-related lncRNAs in the immune response of pancreatic cancer remains unclear. In this study, we identified immune-related lncRNA pairs through a new combinatorial algorithm, and then clustered and deeply analyzed the immune characteristics and functional differences between subtypes. Subsequently, the prognostic model of 3 candidate lncRNA pairs was determined by multivariate COX analysis. The results showed significant prognostic differences between the C1 and C2 subtypes, which may be due to the differential infiltration of CTL and NK cells and the activation of tumor-related pathways. The prognostic model of the 3 lncRNA pairs (AC244035.1_vs._AC063926.1, AC066612.1_vs._AC090124.1, and AC244035.1_vs._LINC01885) was established, which exhibits stable and effective prognostic prediction performance. These 3 lncRNA pairs may regulate the anti-tumor effect of immune cells through ion channel pathways. In conclusion, our research demonstrated the panoramic differences in immune characteristics between subtypes and stable prognostic models, and identified new potential targets for immunotherapy.https://www.frontiersin.org/articles/10.3389/fcell.2021.698296/fullpancreatic cancerimmunotherapyNMFprognosislncRNA pairs |
| spellingShingle | Qiyao Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Zhihui Wang Zhihui Wang Zhihui Wang Zhihui Wang Xiao Yu Xiao Yu Xiao Yu Xiao Yu Menggang Zhang Menggang Zhang Menggang Zhang Menggang Zhang Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Qingyuan Zheng Yuting He Yuting He Yuting He Yuting He Wenzhi Guo Wenzhi Guo Wenzhi Guo Wenzhi Guo Immune Subtypes Based on Immune-Related lncRNA: Differential Prognostic Mechanism of Pancreatic Cancer Frontiers in Cell and Developmental Biology pancreatic cancer immunotherapy NMF prognosis lncRNA pairs |
| title | Immune Subtypes Based on Immune-Related lncRNA: Differential Prognostic Mechanism of Pancreatic Cancer |
| title_full | Immune Subtypes Based on Immune-Related lncRNA: Differential Prognostic Mechanism of Pancreatic Cancer |
| title_fullStr | Immune Subtypes Based on Immune-Related lncRNA: Differential Prognostic Mechanism of Pancreatic Cancer |
| title_full_unstemmed | Immune Subtypes Based on Immune-Related lncRNA: Differential Prognostic Mechanism of Pancreatic Cancer |
| title_short | Immune Subtypes Based on Immune-Related lncRNA: Differential Prognostic Mechanism of Pancreatic Cancer |
| title_sort | immune subtypes based on immune related lncrna differential prognostic mechanism of pancreatic cancer |
| topic | pancreatic cancer immunotherapy NMF prognosis lncRNA pairs |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.698296/full |
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