Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan Africa
The ACE2 gene polymorphisms (rs143936283, rs146676783, and rs4646116) in infected and noninfected persons by SARS-CoV-2 in Burkina Faso. Our cross-sectional study population comprised 137 SARS-CoV-2 infected persons and 181 non-infected persons. Three ACE2 gene polymorphisms rs143936283, rs14667678...
| Principais autores: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
"Alexandru Ioan Cuza" University of Iași
2024-04-01
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| coleção: | Journal of Experimental and Molecular Biology |
| Assuntos: | |
| Acesso em linha: | http://www.jemb.bio.uaic.ro/index.php/jemb/article/view/136 |
| _version_ | 1827280612321394688 |
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| author | Tegwinde Rebeca Compaore Isidore Sawadogo Lassina Traore Abdoul Karim Ouattara Serge Theophile Soubeiga Sylvie Zida Richard Kanfon Vera Sanou Issiaka Soulama Dinanibe Kambire Albert Yonli Oumarou Ouedraogo Charlemagne Dabire Abdoul Nikiema Abdou Zoure Siaka Lougue Tani Sagnaa Dramane Zongo Wendkuuni Florencia Djigma Henri Ouedraogo Jacques Simpore |
| author_facet | Tegwinde Rebeca Compaore Isidore Sawadogo Lassina Traore Abdoul Karim Ouattara Serge Theophile Soubeiga Sylvie Zida Richard Kanfon Vera Sanou Issiaka Soulama Dinanibe Kambire Albert Yonli Oumarou Ouedraogo Charlemagne Dabire Abdoul Nikiema Abdou Zoure Siaka Lougue Tani Sagnaa Dramane Zongo Wendkuuni Florencia Djigma Henri Ouedraogo Jacques Simpore |
| author_sort | Tegwinde Rebeca Compaore |
| collection | DOAJ |
| description |
The ACE2 gene polymorphisms (rs143936283, rs146676783, and rs4646116) in infected and noninfected persons by SARS-CoV-2 in Burkina Faso. Our cross-sectional study population comprised 137 SARS-CoV-2 infected persons and 181 non-infected persons. Three ACE2 gene polymorphisms rs143936283, rs146676783, and rs4646116, were genotyped using the real-time PCR standard TaqMan allelic discrimination technique. The association between SARS-CoV-2 infection and the polymorphisms were evaluated by a binary logistic regression. There was no association between the polymorphisms rs143936283, rs4646116 haplotypes, and SARS-CoV-2 infection in our study population. However, in the female population, the heterozygous genotype CT of rs146676783 increased by two and half the risk (OR=2.58 95%CI (1.2-5.48), p= 0.014) of being infected by SARS-CoV-2. Additionally, carrying the homozygous minor allele (genotype TT) of rs146676783 increased by more than five and half the risk (OR=5.57 95%CI (1.64-18.78), p=0.006) of being infected by SARS-CoV-2 among females. This study showed that the ACE2 gene variant rs146676783 was associated with an increased risk of being infected by SARS-CoV-2 in females, suggesting a need for further investigation to contribute to a better understanding of the African COVID-19 enigma.
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| first_indexed | 2024-04-24T08:42:52Z |
| format | Article |
| id | doaj.art-1b2b4e1ae3964178b8f96ff88c98b3a2 |
| institution | Directory Open Access Journal |
| issn | 2601-6974 |
| language | English |
| last_indexed | 2024-04-24T08:42:52Z |
| publishDate | 2024-04-01 |
| publisher | "Alexandru Ioan Cuza" University of Iași |
| record_format | Article |
| series | Journal of Experimental and Molecular Biology |
| spelling | doaj.art-1b2b4e1ae3964178b8f96ff88c98b3a22024-04-16T14:39:38Zeng"Alexandru Ioan Cuza" University of IașiJournal of Experimental and Molecular Biology2601-69742024-04-0110.47743/jemb-2024-136Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan AfricaTegwinde Rebeca Compaore0Isidore Sawadogo1Lassina Traore2Abdoul Karim Ouattara3Serge Theophile Soubeiga4Sylvie Zida5Richard Kanfon6Vera SanouIssiaka SoulamaDinanibe Kambire7Albert Yonli8Oumarou OuedraogoCharlemagne Dabire9Abdoul Nikiema10Abdou Zoure11Siaka LougueTani Sagnaa12Dramane Zongo13Wendkuuni Florencia Djigma14Henri Ouedraogo15Jacques Simpore16Institut de Recherche en Sciences de la Sante (IRSS/CNRST), Burkina FasoLaboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), UFR/SVT, Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE)Université Norbert Zongo/Centre Universitaire de Manga Institut de Recherche en Sciences de la Santé (IRSS / CNRST), Ouagadougou, Burkina FasoInstitut de Recherche en Sciences de la Santé (IRSS / CNRST)Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), UFR/SVT, Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso. Institut de Recherche en Sciences de la Santé (IRSS / CNRST), Ouagadougou, Burkina FasoCentre de recherche biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso Institut de Recherche en Sciences de la Santé (IRSS / CNRST), Ouagadougou, Burkina Faso Institut de Recherche en Sciences de la Santé (IRSS / CNRST), Ouagadougou, Burkina Faso Institut de Recherche en Sciences de la Santé (IRSS / CNRST), Ouagadougou, Burkina Faso Institut de Recherche en Sciences de la Santé (IRSS / CNRST), Ouagadougou, Burkina Faso Institut de Recherche en Sciences de la Santé (IRSS / CNRST), Ouagadougou, Burkina FasoLaboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), UFR/SVT, Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso. Institut de Recherche en Sciences de la Santé (IRSS / CNRST), Ouagadougou, Burkina Faso Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), UFR/SVT, Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso. The ACE2 gene polymorphisms (rs143936283, rs146676783, and rs4646116) in infected and noninfected persons by SARS-CoV-2 in Burkina Faso. Our cross-sectional study population comprised 137 SARS-CoV-2 infected persons and 181 non-infected persons. Three ACE2 gene polymorphisms rs143936283, rs146676783, and rs4646116, were genotyped using the real-time PCR standard TaqMan allelic discrimination technique. The association between SARS-CoV-2 infection and the polymorphisms were evaluated by a binary logistic regression. There was no association between the polymorphisms rs143936283, rs4646116 haplotypes, and SARS-CoV-2 infection in our study population. However, in the female population, the heterozygous genotype CT of rs146676783 increased by two and half the risk (OR=2.58 95%CI (1.2-5.48), p= 0.014) of being infected by SARS-CoV-2. Additionally, carrying the homozygous minor allele (genotype TT) of rs146676783 increased by more than five and half the risk (OR=5.57 95%CI (1.64-18.78), p=0.006) of being infected by SARS-CoV-2 among females. This study showed that the ACE2 gene variant rs146676783 was associated with an increased risk of being infected by SARS-CoV-2 in females, suggesting a need for further investigation to contribute to a better understanding of the African COVID-19 enigma. http://www.jemb.bio.uaic.ro/index.php/jemb/article/view/136SARS-CoV-2ACE2polymorphismhaplotypesBurkina Faso |
| spellingShingle | Tegwinde Rebeca Compaore Isidore Sawadogo Lassina Traore Abdoul Karim Ouattara Serge Theophile Soubeiga Sylvie Zida Richard Kanfon Vera Sanou Issiaka Soulama Dinanibe Kambire Albert Yonli Oumarou Ouedraogo Charlemagne Dabire Abdoul Nikiema Abdou Zoure Siaka Lougue Tani Sagnaa Dramane Zongo Wendkuuni Florencia Djigma Henri Ouedraogo Jacques Simpore Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan Africa Journal of Experimental and Molecular Biology SARS-CoV-2 ACE2 polymorphism haplotypes Burkina Faso |
| title | Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan Africa |
| title_full | Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan Africa |
| title_fullStr | Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan Africa |
| title_full_unstemmed | Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan Africa |
| title_short | Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan Africa |
| title_sort | linkage between ace2 gene polymorphisms and sars cov 2 infection in burkina faso sub saharan africa |
| topic | SARS-CoV-2 ACE2 polymorphism haplotypes Burkina Faso |
| url | http://www.jemb.bio.uaic.ro/index.php/jemb/article/view/136 |
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