Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cells
Our study investigated lovastatin-induced G1 phase synchronization of HEC-1-A cells and JEC cells and the cell cycle progression after desynchronization of these cells. HEC-1-A cells and JEC cells were treated with by lovastatin and the proportion of cells in G1 phase was detected. Both cell types w...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2013-01-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/12847 |
| _version_ | 1819026444371623936 |
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| author | Huimin Shen Xiaomao Li Yuebo Yang Xiaoyun Wang Xu Zhang |
| author_facet | Huimin Shen Xiaomao Li Yuebo Yang Xiaoyun Wang Xu Zhang |
| author_sort | Huimin Shen |
| collection | DOAJ |
| description | Our study investigated lovastatin-induced G1 phase synchronization of HEC-1-A cells and JEC cells and the cell cycle progression after desynchronization of these cells. HEC-1-A cells and JEC cells were treated with by lovastatin and the proportion of cells in G1 phase was detected. Both cell types were incubated with lovastatin and the synchronization was determined. The cell cycle progression of both cell types was investigated. The proportion of Both cell types in G1 phase was 87.87 ± 0.70% and 85.00 ± 0.79%, respectively. At 20 h and 16 h after G1-phase desynchronization, the proportion of cells in S phase reached a maximal level and that in G1 phase was at the minimal level for HEC-1-A cells and JEC cells, respectively. Thus, at 20 h and 16 h after desynchronization, the proportion of cells in S phase was the highest and that in G1 phase the lowest for HEC-1-A cells and JEC cells, respectively. |
| first_indexed | 2024-12-21T05:26:40Z |
| format | Article |
| id | doaj.art-1b2b98e726cf4e8ab85012a4c5312f8f |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-21T05:26:40Z |
| publishDate | 2013-01-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-1b2b98e726cf4e8ab85012a4c5312f8f2022-12-21T19:14:40ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882013-01-018110.3329/bjp.v8i1.12847Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cellsHuimin Shen0Xiaomao Li1Yuebo Yang2Xiaoyun Wang3Xu Zhang4Department of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-sen University, GuangzhouDepartment of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-sen University, GuangzhouDepartment of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-sen University, GuangzhouDepartment of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-sen University, GuangzhouDepartment of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-sen University, GuangzhouOur study investigated lovastatin-induced G1 phase synchronization of HEC-1-A cells and JEC cells and the cell cycle progression after desynchronization of these cells. HEC-1-A cells and JEC cells were treated with by lovastatin and the proportion of cells in G1 phase was detected. Both cell types were incubated with lovastatin and the synchronization was determined. The cell cycle progression of both cell types was investigated. The proportion of Both cell types in G1 phase was 87.87 ± 0.70% and 85.00 ± 0.79%, respectively. At 20 h and 16 h after G1-phase desynchronization, the proportion of cells in S phase reached a maximal level and that in G1 phase was at the minimal level for HEC-1-A cells and JEC cells, respectively. Thus, at 20 h and 16 h after desynchronization, the proportion of cells in S phase was the highest and that in G1 phase the lowest for HEC-1-A cells and JEC cells, respectively.https://www.banglajol.info/index.php/BJP/article/view/12847Cell cycleG1-phase synchronizationHEC-1-A cellJEC cellLovastatin |
| spellingShingle | Huimin Shen Xiaomao Li Yuebo Yang Xiaoyun Wang Xu Zhang Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cells Bangladesh Journal of Pharmacology Cell cycle G1-phase synchronization HEC-1-A cell JEC cell Lovastatin |
| title | Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cells |
| title_full | Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cells |
| title_fullStr | Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cells |
| title_full_unstemmed | Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cells |
| title_short | Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cells |
| title_sort | lovastatin induces g1 phase synchronization of hec 1 a cells and jec cells |
| topic | Cell cycle G1-phase synchronization HEC-1-A cell JEC cell Lovastatin |
| url | https://www.banglajol.info/index.php/BJP/article/view/12847 |
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