THE COMPARATIVE COST-EFFICACY ANALYSIS OF VARIOUS ANTIHYPERTENSIVE THERAPIES
<p><strong>Aim.</strong> To perform the comparative cost-efficacy analysis of various antihypertensive therapies in hypertensives patients.</p><p><strong>Material and methods.</strong> 140 hypertensive patients with history of ineffective antihypertensive th...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | http://www.rpcardio.ru/jour/article/view/714 |
| _version_ | 1797763198131109888 |
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| author | S. V. Malchikova E. I. Tarlovskaya |
| author_facet | S. V. Malchikova E. I. Tarlovskaya |
| author_sort | S. V. Malchikova |
| collection | DOAJ |
| description | <p><strong>Aim.</strong> To perform the comparative cost-efficacy analysis of various antihypertensive therapies in hypertensives patients.</p><p><strong>Material and methods.</strong> 140 hypertensive patients with history of ineffective antihypertensive therapy were randomized in to 4 groups, 35 patients in each one. Patients of Group A received indapamide retard plus perindopril; group B - indapamide retard plus amlodipine; group C - amlodipine plus lisinopril; group D - amlodipine plus bisoprolol. The Russian version of general questionnaire MOS-SF-36 was applied for quality of a life estimated. Endothelium function was evaluated with B-mode ultrasonography (Acuson 128 ХР/10). Albuminuria level was detected by immunoturbometric method (Integra-700, Roche).</p><p><strong>Results.</strong> The drug combination B had the least cost. The drug combination C was the most effective. The drug combination C was the most economically rational. The drug combination A was the least economically rational for BP reduction. However the drug combination A was comparable with drug combination C in effects on quality of life and on endothelium function, and it was the most economically rational for albuminuria reduction.</p><p><strong>Conclusion.</strong> Indapamide retard plus perindopril combination is the most economically rational in patients with target-organ lesions (nephropathy). Lisinopril plus amlodipine combination is economically rational in patients without target-organ lesions. </p> |
| first_indexed | 2024-03-12T19:38:07Z |
| format | Article |
| id | doaj.art-1b2cdb284bcd40dcb430a4c4ad72d9ce |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-12T19:38:07Z |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-1b2cdb284bcd40dcb430a4c4ad72d9ce2023-08-02T04:01:41ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0155354010.1234/1819-6446-2009-5-35-40713THE COMPARATIVE COST-EFFICACY ANALYSIS OF VARIOUS ANTIHYPERTENSIVE THERAPIESS. V. Malchikova0E. I. Tarlovskaya1Кировская государственная медицинская академияКировская государственная медицинская академия<p><strong>Aim.</strong> To perform the comparative cost-efficacy analysis of various antihypertensive therapies in hypertensives patients.</p><p><strong>Material and methods.</strong> 140 hypertensive patients with history of ineffective antihypertensive therapy were randomized in to 4 groups, 35 patients in each one. Patients of Group A received indapamide retard plus perindopril; group B - indapamide retard plus amlodipine; group C - amlodipine plus lisinopril; group D - amlodipine plus bisoprolol. The Russian version of general questionnaire MOS-SF-36 was applied for quality of a life estimated. Endothelium function was evaluated with B-mode ultrasonography (Acuson 128 ХР/10). Albuminuria level was detected by immunoturbometric method (Integra-700, Roche).</p><p><strong>Results.</strong> The drug combination B had the least cost. The drug combination C was the most effective. The drug combination C was the most economically rational. The drug combination A was the least economically rational for BP reduction. However the drug combination A was comparable with drug combination C in effects on quality of life and on endothelium function, and it was the most economically rational for albuminuria reduction.</p><p><strong>Conclusion.</strong> Indapamide retard plus perindopril combination is the most economically rational in patients with target-organ lesions (nephropathy). Lisinopril plus amlodipine combination is economically rational in patients without target-organ lesions. </p>http://www.rpcardio.ru/jour/article/view/714комбинированная терапияартериальная гипертензияанализ «затраты-эффективность» |
| spellingShingle | S. V. Malchikova E. I. Tarlovskaya THE COMPARATIVE COST-EFFICACY ANALYSIS OF VARIOUS ANTIHYPERTENSIVE THERAPIES Рациональная фармакотерапия в кардиологии комбинированная терапия артериальная гипертензия анализ «затраты-эффективность» |
| title | THE COMPARATIVE COST-EFFICACY ANALYSIS OF VARIOUS ANTIHYPERTENSIVE THERAPIES |
| title_full | THE COMPARATIVE COST-EFFICACY ANALYSIS OF VARIOUS ANTIHYPERTENSIVE THERAPIES |
| title_fullStr | THE COMPARATIVE COST-EFFICACY ANALYSIS OF VARIOUS ANTIHYPERTENSIVE THERAPIES |
| title_full_unstemmed | THE COMPARATIVE COST-EFFICACY ANALYSIS OF VARIOUS ANTIHYPERTENSIVE THERAPIES |
| title_short | THE COMPARATIVE COST-EFFICACY ANALYSIS OF VARIOUS ANTIHYPERTENSIVE THERAPIES |
| title_sort | comparative cost efficacy analysis of various antihypertensive therapies |
| topic | комбинированная терапия артериальная гипертензия анализ «затраты-эффективность» |
| url | http://www.rpcardio.ru/jour/article/view/714 |
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