Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target
Mitochondria are the key source of ATP that fuels cellular functions, and they are also central in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been implicated in a wide range of diseases, including neurodegenerative and cardiac diseases, and various types of canc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00460/full |
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| author | Amadou K. S. Camara Amadou K. S. Camara YiFan Zhou Po-Chao Wen Emad Tajkhorshid Wai-Meng Kwok Wai-Meng Kwok Wai-Meng Kwok |
| author_facet | Amadou K. S. Camara Amadou K. S. Camara YiFan Zhou Po-Chao Wen Emad Tajkhorshid Wai-Meng Kwok Wai-Meng Kwok Wai-Meng Kwok |
| author_sort | Amadou K. S. Camara |
| collection | DOAJ |
| description | Mitochondria are the key source of ATP that fuels cellular functions, and they are also central in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been implicated in a wide range of diseases, including neurodegenerative and cardiac diseases, and various types of cancer. One of the key proteins that regulate mitochondrial function is the voltage-dependent anion channel 1 (VDAC1), the most abundant protein on the outer membrane of mitochondria. VDAC1 is the gatekeeper for the passages of metabolites, nucleotides, and ions; it plays a crucial role in regulating apoptosis due to its interaction with apoptotic and anti-apoptotic proteins, namely members of the Bcl-2 family of proteins and hexokinase. Therefore, regulation of VDAC1 is crucial not only for metabolic functions of mitochondria, but also for cell survival. In fact, multiple lines of evidence have confirmed the involvement of VDAC1 in several diseases. Consequently, modulation or dysregulation of VDAC1 function can potentially attenuate or exacerbate pathophysiological conditions. Understanding the role of VDAC1 in health and disease could lead to selective protection of cells in different tissues and diverse diseases. The purpose of this review is to discuss the role of VDAC1 in the pathogenesis of diseases and as a potentially effective target for therapeutic management of various pathologies. |
| first_indexed | 2024-04-13T11:49:10Z |
| format | Article |
| id | doaj.art-1b2d35c7da1b42c6b5a166728e8b6fc4 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T11:49:10Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-1b2d35c7da1b42c6b5a166728e8b6fc42022-12-22T02:48:06ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-06-01810.3389/fphys.2017.00460242373Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic TargetAmadou K. S. Camara0Amadou K. S. Camara1YiFan Zhou2Po-Chao Wen3Emad Tajkhorshid4Wai-Meng Kwok5Wai-Meng Kwok6Wai-Meng Kwok7Department of Anesthesiology, Medical College of WisconsinMilwaukee, WI, United StatesCardiovascular Center, Medical College of WisconsinMilwaukee, WI, United StatesDepartment of Assay Development, HD BiosciencesShanghai, ChinaDepartment of Biochemistry, Beckman Institute for Advanced Science and Technology, Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-ChampaignUrbana, IL, United StatesDepartment of Biochemistry, Beckman Institute for Advanced Science and Technology, Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-ChampaignUrbana, IL, United StatesDepartment of Anesthesiology, Medical College of WisconsinMilwaukee, WI, United StatesCardiovascular Center, Medical College of WisconsinMilwaukee, WI, United StatesDepartment of Pharmacology and Toxicology, Medical College of WisconsinMilwaukee, WI, United StatesMitochondria are the key source of ATP that fuels cellular functions, and they are also central in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been implicated in a wide range of diseases, including neurodegenerative and cardiac diseases, and various types of cancer. One of the key proteins that regulate mitochondrial function is the voltage-dependent anion channel 1 (VDAC1), the most abundant protein on the outer membrane of mitochondria. VDAC1 is the gatekeeper for the passages of metabolites, nucleotides, and ions; it plays a crucial role in regulating apoptosis due to its interaction with apoptotic and anti-apoptotic proteins, namely members of the Bcl-2 family of proteins and hexokinase. Therefore, regulation of VDAC1 is crucial not only for metabolic functions of mitochondria, but also for cell survival. In fact, multiple lines of evidence have confirmed the involvement of VDAC1 in several diseases. Consequently, modulation or dysregulation of VDAC1 function can potentially attenuate or exacerbate pathophysiological conditions. Understanding the role of VDAC1 in health and disease could lead to selective protection of cells in different tissues and diverse diseases. The purpose of this review is to discuss the role of VDAC1 in the pathogenesis of diseases and as a potentially effective target for therapeutic management of various pathologies.http://journal.frontiersin.org/article/10.3389/fphys.2017.00460/fullmitochondriacardiac ischemia/reperfusionAlzheimer's diseaseneoplastic diseasesmolecular dynamicsvoltage dependent anion channel |
| spellingShingle | Amadou K. S. Camara Amadou K. S. Camara YiFan Zhou Po-Chao Wen Emad Tajkhorshid Wai-Meng Kwok Wai-Meng Kwok Wai-Meng Kwok Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target Frontiers in Physiology mitochondria cardiac ischemia/reperfusion Alzheimer's disease neoplastic diseases molecular dynamics voltage dependent anion channel |
| title | Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target |
| title_full | Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target |
| title_fullStr | Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target |
| title_full_unstemmed | Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target |
| title_short | Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target |
| title_sort | mitochondrial vdac1 a key gatekeeper as potential therapeutic target |
| topic | mitochondria cardiac ischemia/reperfusion Alzheimer's disease neoplastic diseases molecular dynamics voltage dependent anion channel |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2017.00460/full |
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