The Incidence of Cardiovascular Events in Small Versus Large Ischemic Stroke; A Three-Year Cohort Study
INTRODUCTION: Cerebral ischemia and coronary artery disease (CAD), the major leading causes of mortality and morbidity worldwide, are pathophysiologically interrelated. Cerebral ischemic events are categorized as large or small vessels disease. The current study compares the factors related to CAD e...
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| Format: | Article |
| Language: | English |
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Vesnu Publications
2023-09-01
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| Series: | ARYA Atherosclerosis |
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| Online Access: | https://arya.mui.ac.ir/article_30941_fa5927a9268e6dea46d1d5e141704fb0.pdf |
| _version_ | 1797229495506173952 |
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| author | Marzieh Tajmirriahi Mohammad Saadatnia Hassan Shemirani Masoumeh Sadeghi Alireza Chamasemani Ali Safaei |
| author_facet | Marzieh Tajmirriahi Mohammad Saadatnia Hassan Shemirani Masoumeh Sadeghi Alireza Chamasemani Ali Safaei |
| author_sort | Marzieh Tajmirriahi |
| collection | DOAJ |
| description | INTRODUCTION: Cerebral ischemia and coronary artery disease (CAD), the major leading causes of mortality and morbidity worldwide, are pathophysiologically interrelated. Cerebral ischemic events are categorized as large or small vessels disease. The current study compares the factors related to CAD events incidence following ischemic large versus small disease CVA.METHOD: The current cohort study was conducted on 225 patients with ischemic stroke in two groups of large (n=75) and small (n=150) vessel disease during 2018-19. The patients’ demographic, medical, and clinical characteristics were recruited. They were followed for three years regarding the incidence of CAD events, including ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), unstable angina (UA), and sudden cardiac death (SCD). Data about the coronary angiography, computed tomography angiography (CTA), Single Photon Emission Computed Tomography (SPECT), and the therapeutic approach were gathered.RESULTS: There were insignificant differences between the patients with small versus large vessels CVA in terms of ACS incidence (P-value=0.105), type of the events (P-value=0.836), angiographic (P-value=0.671), SPECT (P-value=0.99) and CTA findings (P-value>0.99) and approached CAD (P-value=0.728). Cox regression assessments revealed an increased risk of CAD events due to large versus small vessels disease after adjustments for hypertension, diabetes mellitus, dyslipidemia, re-stroke, and the previous history of IHD (HR=2.005, 95%CI: 1.093-2.988, P-value=0.021).CONCLUSION: According to the findings of this study, large-vessel involvement in an ischemic stroke was associated with more than a two-fold increase in the three-year probability of ischemic heart disease incidencet.
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| first_indexed | 2024-04-24T15:13:30Z |
| format | Article |
| id | doaj.art-1b2e13bd180f430585dc2c5eb7c83ddf |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-04-24T15:13:30Z |
| publishDate | 2023-09-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | ARYA Atherosclerosis |
| spelling | doaj.art-1b2e13bd180f430585dc2c5eb7c83ddf2024-04-02T09:31:29ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382023-09-0119522022710.48305/arya.2023.26660.282030941The Incidence of Cardiovascular Events in Small Versus Large Ischemic Stroke; A Three-Year Cohort StudyMarzieh Tajmirriahi0Mohammad Saadatnia1Hassan Shemirani2Masoumeh Sadeghi3Alireza Chamasemani4Ali Safaei5Hypertension Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, IranInterventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Cardiovascular Research Center, Cardiovascular Research Institute; Isfahan University of Medical Sciences; Isfahan; IranINTRODUCTION: Cerebral ischemia and coronary artery disease (CAD), the major leading causes of mortality and morbidity worldwide, are pathophysiologically interrelated. Cerebral ischemic events are categorized as large or small vessels disease. The current study compares the factors related to CAD events incidence following ischemic large versus small disease CVA.METHOD: The current cohort study was conducted on 225 patients with ischemic stroke in two groups of large (n=75) and small (n=150) vessel disease during 2018-19. The patients’ demographic, medical, and clinical characteristics were recruited. They were followed for three years regarding the incidence of CAD events, including ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), unstable angina (UA), and sudden cardiac death (SCD). Data about the coronary angiography, computed tomography angiography (CTA), Single Photon Emission Computed Tomography (SPECT), and the therapeutic approach were gathered.RESULTS: There were insignificant differences between the patients with small versus large vessels CVA in terms of ACS incidence (P-value=0.105), type of the events (P-value=0.836), angiographic (P-value=0.671), SPECT (P-value=0.99) and CTA findings (P-value>0.99) and approached CAD (P-value=0.728). Cox regression assessments revealed an increased risk of CAD events due to large versus small vessels disease after adjustments for hypertension, diabetes mellitus, dyslipidemia, re-stroke, and the previous history of IHD (HR=2.005, 95%CI: 1.093-2.988, P-value=0.021).CONCLUSION: According to the findings of this study, large-vessel involvement in an ischemic stroke was associated with more than a two-fold increase in the three-year probability of ischemic heart disease incidencet. https://arya.mui.ac.ir/article_30941_fa5927a9268e6dea46d1d5e141704fb0.pdfcoronary artery diseasecardiovascular diseaseischemic strokecohort studies |
| spellingShingle | Marzieh Tajmirriahi Mohammad Saadatnia Hassan Shemirani Masoumeh Sadeghi Alireza Chamasemani Ali Safaei The Incidence of Cardiovascular Events in Small Versus Large Ischemic Stroke; A Three-Year Cohort Study ARYA Atherosclerosis coronary artery disease cardiovascular disease ischemic stroke cohort studies |
| title | The Incidence of Cardiovascular Events in Small Versus Large Ischemic Stroke; A Three-Year Cohort Study |
| title_full | The Incidence of Cardiovascular Events in Small Versus Large Ischemic Stroke; A Three-Year Cohort Study |
| title_fullStr | The Incidence of Cardiovascular Events in Small Versus Large Ischemic Stroke; A Three-Year Cohort Study |
| title_full_unstemmed | The Incidence of Cardiovascular Events in Small Versus Large Ischemic Stroke; A Three-Year Cohort Study |
| title_short | The Incidence of Cardiovascular Events in Small Versus Large Ischemic Stroke; A Three-Year Cohort Study |
| title_sort | incidence of cardiovascular events in small versus large ischemic stroke a three year cohort study |
| topic | coronary artery disease cardiovascular disease ischemic stroke cohort studies |
| url | https://arya.mui.ac.ir/article_30941_fa5927a9268e6dea46d1d5e141704fb0.pdf |
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