Retinal Functional Impairment in Diabetic Retinopathy
Background: Diabetic retinopathy (DR) is a neurodegenerative disease of the retina. The aim of our study was to analyze latency changes in a full-field electroretinogram (ERG) in patients with type 2 diabetes. Material: This prospective study included 15 diabetic patients without DR, 16 diabetic pat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/1/44 |
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| author | Cornelia Andreea Tănasie Alexandra Oltea Dan Oana Maria Ică Maria Filoftea Mercuț George Mitroi Citto-Iulian Taisescu Veronica Sfredel Ramona Ingrid Corbeanu Carmen Luminița Mocanu Ciprian Danielescu |
| author_facet | Cornelia Andreea Tănasie Alexandra Oltea Dan Oana Maria Ică Maria Filoftea Mercuț George Mitroi Citto-Iulian Taisescu Veronica Sfredel Ramona Ingrid Corbeanu Carmen Luminița Mocanu Ciprian Danielescu |
| author_sort | Cornelia Andreea Tănasie |
| collection | DOAJ |
| description | Background: Diabetic retinopathy (DR) is a neurodegenerative disease of the retina. The aim of our study was to analyze latency changes in a full-field electroretinogram (ERG) in patients with type 2 diabetes. Material: This prospective study included 15 diabetic patients without DR, 16 diabetic patients with non-proliferative DR, 14 patients with pre-proliferative DR, 15 patients with proliferative DR, and 14 age-matched controls. All the participants underwent ophthalmologic examination and full-field ERGs. The ERGs were recorded with the Metrovision MonPackOne system. The latencies were analyzed for “a”- and “b”-waves in the dark-adapted (DA) 0.01 ERG, DA 3.0 ERG, DA oscillatory potentials, light-adapted (LA) 3.0 ERG, and 30 Hz flicker ERG. Results: The delayed responses of healthy subjects compared to diabetic patients without DR were the DA oscillatory potentials (25.45 ± 1.04 ms vs. 26.15 ± 0.96 ms, <i>p</i> = 0.027). When comparing diabetic patients without DR and with non-proliferative DR, we did not obtain statistically significant delays. Significant delays in the DA 0.01 “b”-wave (61.91 ± 5.52 ms vs. 66.36 ± 8.12 ms, <i>p</i> = 0.029), DA 3.0 “b”-wave (41.01 ± 2.50 ms vs. 44.16 ± 3.78 ms, <i>p</i> = 0.035), and LA 3.0 “a”-wave (16.21 ± 0.91 ms vs. 16.99 ± 1.16 ms, <i>p</i> = 0.045) were found between non-proliferative DR and pre-proliferative DR. When comparing the groups of patients with pre-proliferative DR and proliferative DR, the LA 3.0 ERG “b”-wave (32. 63 ± 2.53 ms vs. 36.19 ± 3.21 ms, <i>p</i> < 0.0001), LA 30 Hz flicker ERG “a”-wave (19.56 ± 3.59 vs. 21.75 ± 4.74 ms, <i>p</i>= 0.025), and “b”-wave (32.23 ± 4.02 vs. 36.68 ± 3.48 ms, <i>p</i> = 0.017) were delayed. Conclusions: the electrophysiological findings from our study indicate that there is a substantial dysfunction of the neural retina in all stages of DR. |
| first_indexed | 2024-03-08T09:57:30Z |
| format | Article |
| id | doaj.art-1b2f23e01b9248a5b01d4070cf3ea929 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T09:57:30Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1b2f23e01b9248a5b01d4070cf3ea9292024-01-29T13:46:43ZengMDPI AGBiomedicines2227-90592023-12-011214410.3390/biomedicines12010044Retinal Functional Impairment in Diabetic RetinopathyCornelia Andreea Tănasie0Alexandra Oltea Dan1Oana Maria Ică2Maria Filoftea Mercuț3George Mitroi4Citto-Iulian Taisescu5Veronica Sfredel6Ramona Ingrid Corbeanu7Carmen Luminița Mocanu8Ciprian Danielescu9Department of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Dermatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Ophthalmology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Urology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Ophthalmology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Ophthalmology, University of Medicine and Pharmacy “Grigore T. Popa”, 700111 Iasi, RomaniaBackground: Diabetic retinopathy (DR) is a neurodegenerative disease of the retina. The aim of our study was to analyze latency changes in a full-field electroretinogram (ERG) in patients with type 2 diabetes. Material: This prospective study included 15 diabetic patients without DR, 16 diabetic patients with non-proliferative DR, 14 patients with pre-proliferative DR, 15 patients with proliferative DR, and 14 age-matched controls. All the participants underwent ophthalmologic examination and full-field ERGs. The ERGs were recorded with the Metrovision MonPackOne system. The latencies were analyzed for “a”- and “b”-waves in the dark-adapted (DA) 0.01 ERG, DA 3.0 ERG, DA oscillatory potentials, light-adapted (LA) 3.0 ERG, and 30 Hz flicker ERG. Results: The delayed responses of healthy subjects compared to diabetic patients without DR were the DA oscillatory potentials (25.45 ± 1.04 ms vs. 26.15 ± 0.96 ms, <i>p</i> = 0.027). When comparing diabetic patients without DR and with non-proliferative DR, we did not obtain statistically significant delays. Significant delays in the DA 0.01 “b”-wave (61.91 ± 5.52 ms vs. 66.36 ± 8.12 ms, <i>p</i> = 0.029), DA 3.0 “b”-wave (41.01 ± 2.50 ms vs. 44.16 ± 3.78 ms, <i>p</i> = 0.035), and LA 3.0 “a”-wave (16.21 ± 0.91 ms vs. 16.99 ± 1.16 ms, <i>p</i> = 0.045) were found between non-proliferative DR and pre-proliferative DR. When comparing the groups of patients with pre-proliferative DR and proliferative DR, the LA 3.0 ERG “b”-wave (32. 63 ± 2.53 ms vs. 36.19 ± 3.21 ms, <i>p</i> < 0.0001), LA 30 Hz flicker ERG “a”-wave (19.56 ± 3.59 vs. 21.75 ± 4.74 ms, <i>p</i>= 0.025), and “b”-wave (32.23 ± 4.02 vs. 36.68 ± 3.48 ms, <i>p</i> = 0.017) were delayed. Conclusions: the electrophysiological findings from our study indicate that there is a substantial dysfunction of the neural retina in all stages of DR.https://www.mdpi.com/2227-9059/12/1/44full-field ERGdiabetes mellitusdiabetic retinopathy |
| spellingShingle | Cornelia Andreea Tănasie Alexandra Oltea Dan Oana Maria Ică Maria Filoftea Mercuț George Mitroi Citto-Iulian Taisescu Veronica Sfredel Ramona Ingrid Corbeanu Carmen Luminița Mocanu Ciprian Danielescu Retinal Functional Impairment in Diabetic Retinopathy Biomedicines full-field ERG diabetes mellitus diabetic retinopathy |
| title | Retinal Functional Impairment in Diabetic Retinopathy |
| title_full | Retinal Functional Impairment in Diabetic Retinopathy |
| title_fullStr | Retinal Functional Impairment in Diabetic Retinopathy |
| title_full_unstemmed | Retinal Functional Impairment in Diabetic Retinopathy |
| title_short | Retinal Functional Impairment in Diabetic Retinopathy |
| title_sort | retinal functional impairment in diabetic retinopathy |
| topic | full-field ERG diabetes mellitus diabetic retinopathy |
| url | https://www.mdpi.com/2227-9059/12/1/44 |
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