Cut-off Levels of CRP to Predict Outcomes in Patients with Influenza Infection
Introduction: Seasonal flu is an acute viral infection caused by an influenza virus. People with weakened or suppressed immune system and people with existing chronic disorders are at a greater risk of serious complications after exposure to influenza virus infection. Therefore, determining prognost...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2018-06-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/11695/35263_CE(Ra1)_F(SS)_PF1(AB_SS)_PFA(OM)_PB(SL)_PN(SL).pdf |
| _version_ | 1818305909316648960 |
|---|---|
| author | Omer Karasahin Hasan Selçuk Özger Rezan Harman Sibel Iba Yilmaz |
| author_facet | Omer Karasahin Hasan Selçuk Özger Rezan Harman Sibel Iba Yilmaz |
| author_sort | Omer Karasahin |
| collection | DOAJ |
| description | Introduction: Seasonal flu is an acute viral infection caused by an influenza virus. People with weakened or suppressed immune system and people with existing chronic disorders are at a greater risk of serious complications after exposure to influenza virus infection. Therefore, determining prognostic markers that are practical, accessible and assessable within the first 24 hours of admission, is of great importance. Aim: To determine the cut-off levels for several bio-chemical markers to predict mortality and determine which patient would require ICU admission in adults with Influenza A infection. Materials and Methods: All patients (155) included in the study were above the age of 18 years and diagnosed with Influenza A from December 2015 to March 2016. ROC analysis, Cox regression model and Kaplan-Meier analysis were used to determine the prognostic predictions of the biomarkers, C-Reactive Protein (CRP), Creatine Kinase (CK) and risk factors. Results: Serum CRP and CK levels were significantly high in patients who required ICU support or died. The highest sensitivity and specificity cut-off value for mortality and intensive care unit needs was 76.5 mg/L for CRP. The highest sensitivity and specificity cut-off value for mortality prediction of CK was 234 U/L, and that for intensive care unit needs was 302 U/L. With each 1 mg/L increase in serum CRP values, the risk of mortality increased by 1.007 times (95% CI 1.001-1.013; p=0.017). The mean life span of patients with serum CRP levels above 76.5 mg/L was shortened. Conclusion: The cut-off value of CRP for ICU admission and mortality was indicated as 76.5 mg/L. The frequency of development of mortality in cases below this limit value was determined as <1% and survival times were found significantly longer. |
| first_indexed | 2024-12-13T06:34:05Z |
| format | Article |
| id | doaj.art-1b30feeb99394f5c96242fdab38d7ea0 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-13T06:34:05Z |
| publishDate | 2018-06-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-1b30feeb99394f5c96242fdab38d7ea02022-12-21T23:56:33ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-06-01126DC56DC6010.7860/JCDR/2018/35263.11695Cut-off Levels of CRP to Predict Outcomes in Patients with Influenza InfectionOmer Karasahin0Hasan Selçuk Özger1Rezan Harman2Sibel Iba Yilmaz3Consultant, Department of Infectious Diseases, Erzurum Regional Education and Research Hospital, Erzurum, Turkey.Consultant, Department of Infectious Diseases, Dr. Ersin Arslan Regional Education and Research Hospital, Gaziantep, Turkey.Consultant, Department of Infectious Diseases, Gaziantep SANKO Hospital, Gaziantep, Turkey.Consultant, Department of Infectious Diseases, Erzurum Regional Education and Research Hospital, Erzurum, Turkey.Introduction: Seasonal flu is an acute viral infection caused by an influenza virus. People with weakened or suppressed immune system and people with existing chronic disorders are at a greater risk of serious complications after exposure to influenza virus infection. Therefore, determining prognostic markers that are practical, accessible and assessable within the first 24 hours of admission, is of great importance. Aim: To determine the cut-off levels for several bio-chemical markers to predict mortality and determine which patient would require ICU admission in adults with Influenza A infection. Materials and Methods: All patients (155) included in the study were above the age of 18 years and diagnosed with Influenza A from December 2015 to March 2016. ROC analysis, Cox regression model and Kaplan-Meier analysis were used to determine the prognostic predictions of the biomarkers, C-Reactive Protein (CRP), Creatine Kinase (CK) and risk factors. Results: Serum CRP and CK levels were significantly high in patients who required ICU support or died. The highest sensitivity and specificity cut-off value for mortality and intensive care unit needs was 76.5 mg/L for CRP. The highest sensitivity and specificity cut-off value for mortality prediction of CK was 234 U/L, and that for intensive care unit needs was 302 U/L. With each 1 mg/L increase in serum CRP values, the risk of mortality increased by 1.007 times (95% CI 1.001-1.013; p=0.017). The mean life span of patients with serum CRP levels above 76.5 mg/L was shortened. Conclusion: The cut-off value of CRP for ICU admission and mortality was indicated as 76.5 mg/L. The frequency of development of mortality in cases below this limit value was determined as <1% and survival times were found significantly longer.https://jcdr.net/articles/PDF/11695/35263_CE(Ra1)_F(SS)_PF1(AB_SS)_PFA(OM)_PB(SL)_PN(SL).pdfc-reactive proteincreatine kinaseintensive care unit |
| spellingShingle | Omer Karasahin Hasan Selçuk Özger Rezan Harman Sibel Iba Yilmaz Cut-off Levels of CRP to Predict Outcomes in Patients with Influenza Infection Journal of Clinical and Diagnostic Research c-reactive protein creatine kinase intensive care unit |
| title | Cut-off Levels of CRP to Predict Outcomes in Patients with Influenza Infection |
| title_full | Cut-off Levels of CRP to Predict Outcomes in Patients with Influenza Infection |
| title_fullStr | Cut-off Levels of CRP to Predict Outcomes in Patients with Influenza Infection |
| title_full_unstemmed | Cut-off Levels of CRP to Predict Outcomes in Patients with Influenza Infection |
| title_short | Cut-off Levels of CRP to Predict Outcomes in Patients with Influenza Infection |
| title_sort | cut off levels of crp to predict outcomes in patients with influenza infection |
| topic | c-reactive protein creatine kinase intensive care unit |
| url | https://jcdr.net/articles/PDF/11695/35263_CE(Ra1)_F(SS)_PF1(AB_SS)_PFA(OM)_PB(SL)_PN(SL).pdf |
| work_keys_str_mv | AT omerkarasahin cutofflevelsofcrptopredictoutcomesinpatientswithinfluenzainfection AT hasanselcukozger cutofflevelsofcrptopredictoutcomesinpatientswithinfluenzainfection AT rezanharman cutofflevelsofcrptopredictoutcomesinpatientswithinfluenzainfection AT sibelibayilmaz cutofflevelsofcrptopredictoutcomesinpatientswithinfluenzainfection |