Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies
(1) Background: Uncontrolled inflammation often contributes to life-threatening sepsis sequela such as multi-organ dysfunction syndrome (MODS), and is accompanied by abnormal levels of pathological and damage-associated molecular patterns (PAMPs & DAMPs) in biological fluids. Activated carbon or...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | C |
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| Online Access: | https://www.mdpi.com/2311-5629/9/3/72 |
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| author | Elisaveta Snezhkova Heinz Redl Johannes Grillari Marcin Osuchowski |
| author_facet | Elisaveta Snezhkova Heinz Redl Johannes Grillari Marcin Osuchowski |
| author_sort | Elisaveta Snezhkova |
| collection | DOAJ |
| description | (1) Background: Uncontrolled inflammation often contributes to life-threatening sepsis sequela such as multi-organ dysfunction syndrome (MODS), and is accompanied by abnormal levels of pathological and damage-associated molecular patterns (PAMPs & DAMPs) in biological fluids. Activated carbon or charcoal (AC) of new generation with ameliorated biocompatibility has spurred renewed interest in the regulation of these toxins’ levels in inflammation states. (2) Methods: We searched PubMed, Google Scholar, ScienceDirect, Researchgate, and other sources for the relevant literature from 1550 B.C. till 2022 A.C. (3) Results: Laboratory and clinical investigations demonstrate that activated carbon or charcoal (AC) mitigates inflammation in different pathological states when applied orally, per rectum, or in a hemoperfusion system. AC protects the microbiome and bone marrow, acts as an anti-inflammatory and anti-oxidant remedy, and recovers the plasmatic albumin structure. The mechanism of AC action is related to a non-selective (broad-range) or/and selective adsorption of PAMPs & DAMPs from biological fluids. A high-adsorptive capacity towards noxious substances and application of AC as early as possible seems paramount in inflammation treatment for preventing sepsis and/or multi-organ failure. (4) Conclusion: AC could be considered an adjunctive treatment for preventing sepsis and/or multi-organ failure. |
| first_indexed | 2024-03-10T22:55:59Z |
| format | Article |
| id | doaj.art-1b31bc5c68a14921881cf7a9b705d955 |
| institution | Directory Open Access Journal |
| issn | 2311-5629 |
| language | English |
| last_indexed | 2024-03-10T22:55:59Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | C |
| spelling | doaj.art-1b31bc5c68a14921881cf7a9b705d9552023-11-19T09:57:13ZengMDPI AGC2311-56292023-07-01937210.3390/c9030072Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old TherapiesElisaveta Snezhkova0Heinz Redl1Johannes Grillari2Marcin Osuchowski3Department of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, UkraineLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, LBG, Donaueschingenstrasse 13, 1200 Vienna, AustriaLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, LBG, Donaueschingenstrasse 13, 1200 Vienna, AustriaLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, LBG, Donaueschingenstrasse 13, 1200 Vienna, Austria(1) Background: Uncontrolled inflammation often contributes to life-threatening sepsis sequela such as multi-organ dysfunction syndrome (MODS), and is accompanied by abnormal levels of pathological and damage-associated molecular patterns (PAMPs & DAMPs) in biological fluids. Activated carbon or charcoal (AC) of new generation with ameliorated biocompatibility has spurred renewed interest in the regulation of these toxins’ levels in inflammation states. (2) Methods: We searched PubMed, Google Scholar, ScienceDirect, Researchgate, and other sources for the relevant literature from 1550 B.C. till 2022 A.C. (3) Results: Laboratory and clinical investigations demonstrate that activated carbon or charcoal (AC) mitigates inflammation in different pathological states when applied orally, per rectum, or in a hemoperfusion system. AC protects the microbiome and bone marrow, acts as an anti-inflammatory and anti-oxidant remedy, and recovers the plasmatic albumin structure. The mechanism of AC action is related to a non-selective (broad-range) or/and selective adsorption of PAMPs & DAMPs from biological fluids. A high-adsorptive capacity towards noxious substances and application of AC as early as possible seems paramount in inflammation treatment for preventing sepsis and/or multi-organ failure. (4) Conclusion: AC could be considered an adjunctive treatment for preventing sepsis and/or multi-organ failure.https://www.mdpi.com/2311-5629/9/3/72activated carbonactivated charcoalsepsisinflammationpathogen-associated molecular patternsdamage-associated molecular patterns |
| spellingShingle | Elisaveta Snezhkova Heinz Redl Johannes Grillari Marcin Osuchowski Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies C activated carbon activated charcoal sepsis inflammation pathogen-associated molecular patterns damage-associated molecular patterns |
| title | Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies |
| title_full | Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies |
| title_fullStr | Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies |
| title_full_unstemmed | Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies |
| title_short | Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies |
| title_sort | activated carbon for sepsis prevention and intervention a modern way of utilizing old therapies |
| topic | activated carbon activated charcoal sepsis inflammation pathogen-associated molecular patterns damage-associated molecular patterns |
| url | https://www.mdpi.com/2311-5629/9/3/72 |
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