Haplotyping SNPs for allele-specific gene editing of the expanded huntingtin allele using long-read sequencing

Haplotyping SNPs for allele-specific gene editing of the expanded huntingtin allele using long-read sequencing

Show other versions (1)

Summary: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by CAG trinucleotide repeat expansions in exon-1 of huntingtin (HTT). Currently, there is no cure for HD, and the clinical care of individuals with HD is focused on symptom management. Previously, we showed...

Descrición completa

Detalles Bibliográficos
Main Authors: Li Fang, Alex Mas Monteys, Alexandra Dürr, Megan Keiser, Congsheng Cheng, Akhil Harapanahalli, Pedro Gonzalez-Alegre, Beverly L. Davidson, Kai Wang
Formato: Artigo
Idioma:English
Publicado: Elsevier 2023-01-01
Series:HGG Advances
Subjects:
Huntington’s disease
long-read sequencing
CRISPR
SNP
repeat detection
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S266624772200063X

Internet

http://www.sciencedirect.com/science/article/pii/S266624772200063X

Títulos similares