Role of parathyroid hormone-related protein in breast cancer detection and prognosis
Currently, there are limited data supporting the use of parathyroid hormone-related protein for the purposes of breast cancer detection and disease prognosis. This literature review covers research results on diagnostic potential of parathyroid hormone-related protein as a biomarker for breast cance...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1
2022-09-01
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| Series: | Инновационная медицина Кубани |
| Subjects: | |
| Online Access: | https://www.innovmedkub.ru/jour/article/view/577 |
| _version_ | 1797276862089527296 |
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| author | A. S. Shatokhina I. M. Bykov E. F. Filippov V. A. Porhanov A. N. Kurzanov |
| author_facet | A. S. Shatokhina I. M. Bykov E. F. Filippov V. A. Porhanov A. N. Kurzanov |
| author_sort | A. S. Shatokhina |
| collection | DOAJ |
| description | Currently, there are limited data supporting the use of parathyroid hormone-related protein for the purposes of breast cancer detection and disease prognosis. This literature review covers research results on diagnostic potential of parathyroid hormone-related protein as a biomarker for breast cancer, as well as the information available in the scientific literature, reflecting obvious contradictions regarding clinical and prognostic importance of this protein in the primary breast cancer, correlation of its expression with the risk of bone metastasis and survival of patients. Results of preclinical and clinical research show, that parathyroid hormone-related protein inhibits tumor progression and decreases its metastasis at early stages of the disease, which improves the survival rate, but it has an opposite effect at the advanced stages of cancer, as it increases tumor development and metastasis, and reduces survival rates. Altogether, these studies prove an idea that parathyroid hormone-related protein plays a double role in breast cancer. Use of parathyroid hormone-related protein for breast cancer early detection and disease prognosis is currently becoming a subject of detailed scientific research studies, which is confirmed by the facts presented in this literature review. |
| first_indexed | 2024-03-07T15:35:26Z |
| format | Article |
| id | doaj.art-1b36f96364364f2aa1fe1b918e48690a |
| institution | Directory Open Access Journal |
| issn | 2541-9897 |
| language | Russian |
| last_indexed | 2024-03-07T15:35:26Z |
| publishDate | 2022-09-01 |
| publisher | Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1 |
| record_format | Article |
| series | Инновационная медицина Кубани |
| spelling | doaj.art-1b36f96364364f2aa1fe1b918e48690a2024-03-05T11:12:31ZrusScientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1Инновационная медицина Кубани2541-98972022-09-0103798610.35401/2541-9897-2022-25-3-79-86343Role of parathyroid hormone-related protein in breast cancer detection and prognosisA. S. Shatokhina0I. M. Bykov1E. F. Filippov2V. A. Porhanov3A. N. Kurzanov4Clinical Oncology Dispensary no. 1Kuban State Medical UniversityKuban State Medical UniversityKuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1Kuban State Medical UniversityCurrently, there are limited data supporting the use of parathyroid hormone-related protein for the purposes of breast cancer detection and disease prognosis. This literature review covers research results on diagnostic potential of parathyroid hormone-related protein as a biomarker for breast cancer, as well as the information available in the scientific literature, reflecting obvious contradictions regarding clinical and prognostic importance of this protein in the primary breast cancer, correlation of its expression with the risk of bone metastasis and survival of patients. Results of preclinical and clinical research show, that parathyroid hormone-related protein inhibits tumor progression and decreases its metastasis at early stages of the disease, which improves the survival rate, but it has an opposite effect at the advanced stages of cancer, as it increases tumor development and metastasis, and reduces survival rates. Altogether, these studies prove an idea that parathyroid hormone-related protein plays a double role in breast cancer. Use of parathyroid hormone-related protein for breast cancer early detection and disease prognosis is currently becoming a subject of detailed scientific research studies, which is confirmed by the facts presented in this literature review.https://www.innovmedkub.ru/jour/article/view/577breast cancerbiomarkerdisease development prognosis |
| spellingShingle | A. S. Shatokhina I. M. Bykov E. F. Filippov V. A. Porhanov A. N. Kurzanov Role of parathyroid hormone-related protein in breast cancer detection and prognosis Инновационная медицина Кубани breast cancer biomarker disease development prognosis |
| title | Role of parathyroid hormone-related protein in breast cancer detection and prognosis |
| title_full | Role of parathyroid hormone-related protein in breast cancer detection and prognosis |
| title_fullStr | Role of parathyroid hormone-related protein in breast cancer detection and prognosis |
| title_full_unstemmed | Role of parathyroid hormone-related protein in breast cancer detection and prognosis |
| title_short | Role of parathyroid hormone-related protein in breast cancer detection and prognosis |
| title_sort | role of parathyroid hormone related protein in breast cancer detection and prognosis |
| topic | breast cancer biomarker disease development prognosis |
| url | https://www.innovmedkub.ru/jour/article/view/577 |
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