Neurotrophins in carotid atherosclerosis and stenting
AbstractIntroduction Carotid stenting is used with an expanding indications. The neurotrophins are a family of proteins that induce the survival, development, and function of neurons. Carotid stenting alters cerebral blood flow and can affect neurotrophins’ levels.Material and methods We included 78...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2022.2163052 |
| _version_ | 1827380518129238016 |
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| author | Teodora Yaneva-Sirakova Latchezar Traykov Kiril Karamfiloff Ivo Petrov Julieta Hristova Dobrin Vassilev |
| author_facet | Teodora Yaneva-Sirakova Latchezar Traykov Kiril Karamfiloff Ivo Petrov Julieta Hristova Dobrin Vassilev |
| author_sort | Teodora Yaneva-Sirakova |
| collection | DOAJ |
| description | AbstractIntroduction Carotid stenting is used with an expanding indications. The neurotrophins are a family of proteins that induce the survival, development, and function of neurons. Carotid stenting alters cerebral blood flow and can affect neurotrophins’ levels.Material and methods We included 78 people: 39 with significant carotid stenoses (CS) referred for carotid stenting (mean age 67.79 ± 10.53 years) and relatively healthy control group of 39 people without carotid and vertebral artery disease (mean age 57.42 ± 15.77 years). Brain derived reurotrophic factor (BDNF) and neuronal growth factor (NGF) concentrations were evaluated with ELISA method from venous blood – once for the control group; and for the carotid stenting group: before (n33), 24 h after (n22) and at least 1 month after (n18) carotid stenting.Results There was a difference between the mean neurotrophins’ concentration of patients with significant carotid stenoses and the group without: BDNF p = 0.001, CI (-5.11 to −1.44) (3.10 ± 3.10 ng/ml in CS vs. 6.37 ± 4.67 ng/ml in controls); NGF p = 0.049, CI (0.64–347.75), 195.67 ± 495.34 pg/ml in CS vs. 21.48 ± 52.81 pg/ml in controls. BDNF levels before carotid stenting (3.10 ± 3.10 ng/ml) were significantly lower than the postprocedural (4.99 ± 2.57 ng/ml) – p < 0.0001, CI (-2.86 to −0.99). For NGF there was a tendency for lower values after stenting: 195.67 ± 495.34 pg/ml before vs. 94.92 ± 120.06 pg/ml after, but the result did not reach statistical significance. The neurotrophins levels one month after carotid stenting and controls’ were not significantly different p < 0.01 (BDNF 5.03 ± 4.75 ng/ml vs. 6.37 ± 4.67 ng/min; NGF 47.89 ± 54.68 pg/ml vs. 21.48 pg/ml).Discussion and conclusion Periprocedural and mid-term concentrations of neurotrophins after carotid stenting change in non-linear model. This may be due to changes in cerebral perfusion and also might be involved in neuronal recovery and reparation after reperfusion.KEY MESSAGESPeriprocedural and mid-term concentrations of neurotrophins after carotid stenting change in non-linear model.As the majority of them are not specific, their periprocedural change can be used as a clinical correlate to guide changes or even success in carotid stenting.Changes in neutrophins’ concentrations may be due to changes in cerebral perfusion and also might be involved in neuronal recovery and reparation after reperfusion.This goes in analogy with cardiac high-sensitive troponin, used as procedural guidance in coronary interventions. |
| first_indexed | 2024-03-08T13:35:04Z |
| format | Article |
| id | doaj.art-1b383a61fc2d47c5a4d203962b2bc4e8 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:35:04Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-1b383a61fc2d47c5a4d203962b2bc4e82024-01-16T19:13:21ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155133534110.1080/07853890.2022.2163052Neurotrophins in carotid atherosclerosis and stentingTeodora Yaneva-Sirakova0Latchezar Traykov1Kiril Karamfiloff2Ivo Petrov3Julieta Hristova4Dobrin Vassilev5Acibadem City Clinic UMHAT, Sofia, BulgariaDepartment of Neurology, UMHAT “Alexandrovska”, Neurology Clinic, Medical University Sofia, Sofia, BulgariaDepartment of Internal medicine, UMHAT “Alexandrovska”, Cardiology Clinic, Medical University Sofia, Sofia, BulgariaAcibadem City Clinic UMHAT, Sofia, BulgariaDepartment of Clinical Laboratory and Drug Toxicity, UMHAT “Alexandrovska” Clinical laboratory, Medical University Sofia, Sofia, BulgariaDepartment of Health Care, UMHAT “Medica Cor”, Ruse, University of Ruse “Angel Kanchev”, Ruse, BulgariaAbstractIntroduction Carotid stenting is used with an expanding indications. The neurotrophins are a family of proteins that induce the survival, development, and function of neurons. Carotid stenting alters cerebral blood flow and can affect neurotrophins’ levels.Material and methods We included 78 people: 39 with significant carotid stenoses (CS) referred for carotid stenting (mean age 67.79 ± 10.53 years) and relatively healthy control group of 39 people without carotid and vertebral artery disease (mean age 57.42 ± 15.77 years). Brain derived reurotrophic factor (BDNF) and neuronal growth factor (NGF) concentrations were evaluated with ELISA method from venous blood – once for the control group; and for the carotid stenting group: before (n33), 24 h after (n22) and at least 1 month after (n18) carotid stenting.Results There was a difference between the mean neurotrophins’ concentration of patients with significant carotid stenoses and the group without: BDNF p = 0.001, CI (-5.11 to −1.44) (3.10 ± 3.10 ng/ml in CS vs. 6.37 ± 4.67 ng/ml in controls); NGF p = 0.049, CI (0.64–347.75), 195.67 ± 495.34 pg/ml in CS vs. 21.48 ± 52.81 pg/ml in controls. BDNF levels before carotid stenting (3.10 ± 3.10 ng/ml) were significantly lower than the postprocedural (4.99 ± 2.57 ng/ml) – p < 0.0001, CI (-2.86 to −0.99). For NGF there was a tendency for lower values after stenting: 195.67 ± 495.34 pg/ml before vs. 94.92 ± 120.06 pg/ml after, but the result did not reach statistical significance. The neurotrophins levels one month after carotid stenting and controls’ were not significantly different p < 0.01 (BDNF 5.03 ± 4.75 ng/ml vs. 6.37 ± 4.67 ng/min; NGF 47.89 ± 54.68 pg/ml vs. 21.48 pg/ml).Discussion and conclusion Periprocedural and mid-term concentrations of neurotrophins after carotid stenting change in non-linear model. This may be due to changes in cerebral perfusion and also might be involved in neuronal recovery and reparation after reperfusion.KEY MESSAGESPeriprocedural and mid-term concentrations of neurotrophins after carotid stenting change in non-linear model.As the majority of them are not specific, their periprocedural change can be used as a clinical correlate to guide changes or even success in carotid stenting.Changes in neutrophins’ concentrations may be due to changes in cerebral perfusion and also might be involved in neuronal recovery and reparation after reperfusion.This goes in analogy with cardiac high-sensitive troponin, used as procedural guidance in coronary interventions.https://www.tandfonline.com/doi/10.1080/07853890.2022.2163052BDNFNGFcarotid disease |
| spellingShingle | Teodora Yaneva-Sirakova Latchezar Traykov Kiril Karamfiloff Ivo Petrov Julieta Hristova Dobrin Vassilev Neurotrophins in carotid atherosclerosis and stenting Annals of Medicine BDNF NGF carotid disease |
| title | Neurotrophins in carotid atherosclerosis and stenting |
| title_full | Neurotrophins in carotid atherosclerosis and stenting |
| title_fullStr | Neurotrophins in carotid atherosclerosis and stenting |
| title_full_unstemmed | Neurotrophins in carotid atherosclerosis and stenting |
| title_short | Neurotrophins in carotid atherosclerosis and stenting |
| title_sort | neurotrophins in carotid atherosclerosis and stenting |
| topic | BDNF NGF carotid disease |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2022.2163052 |
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