Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor Agents
Two series of naphtho[1,8-ef][1,4]diazepines and pyrrolo[1,2-a]perimidines were prepared starting from 1,8-diaminonaphthalene and hydrazonoyl chlorides. The structures of the products were determined on the basis of their spectral data and elemental analyses. The mechanism of formation of such produ...
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| Format: | Article |
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MDPI AG
2014-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/1/740 |
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| author | Thoraya A. Farghaly Eman M. H. Abbas Kamal M. Dawood Tarek B. A. El-Naggar |
| author_facet | Thoraya A. Farghaly Eman M. H. Abbas Kamal M. Dawood Tarek B. A. El-Naggar |
| author_sort | Thoraya A. Farghaly |
| collection | DOAJ |
| description | Two series of naphtho[1,8-ef][1,4]diazepines and pyrrolo[1,2-a]perimidines were prepared starting from 1,8-diaminonaphthalene and hydrazonoyl chlorides. The structures of the products were determined on the basis of their spectral data and elemental analyses. The mechanism of formation of such products was also discussed. The prepared compounds were screened for their antitumor activity against three cell lines, namely, MCF-7, TK-10 and UACC-62, and some derivatives showed promising activity. |
| first_indexed | 2024-12-20T06:36:43Z |
| format | Article |
| id | doaj.art-1b38430ed971442f8a21e923721722f5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T06:36:43Z |
| publishDate | 2014-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1b38430ed971442f8a21e923721722f52022-12-21T19:49:58ZengMDPI AGMolecules1420-30492014-01-0119174075510.3390/molecules19010740molecules19010740Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor AgentsThoraya A. Farghaly0Eman M. H. Abbas1Kamal M. Dawood2Tarek B. A. El-Naggar3Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, EgyptDepartment of Chemistry, Natural and Microbial Products, National Research Center, Dokki, Cairo 12622, EgyptDepartment of Chemistry, Faculty of Science, University of Cairo, Giza 12613, EgyptDepartment of Chemistry, Natural and Microbial Products, National Research Center, Dokki, Cairo 12622, EgyptTwo series of naphtho[1,8-ef][1,4]diazepines and pyrrolo[1,2-a]perimidines were prepared starting from 1,8-diaminonaphthalene and hydrazonoyl chlorides. The structures of the products were determined on the basis of their spectral data and elemental analyses. The mechanism of formation of such products was also discussed. The prepared compounds were screened for their antitumor activity against three cell lines, namely, MCF-7, TK-10 and UACC-62, and some derivatives showed promising activity.http://www.mdpi.com/1420-3049/19/1/7401,8-diaminonaphthalenenaphtho[1,8-ef][1,4]diazepinespyrrolo[1,2-a] perimidineshydrazonoyl chlorideantitumor activity |
| spellingShingle | Thoraya A. Farghaly Eman M. H. Abbas Kamal M. Dawood Tarek B. A. El-Naggar Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor Agents Molecules 1,8-diaminonaphthalene naphtho[1,8-ef][1,4]diazepines pyrrolo[1,2-a] perimidines hydrazonoyl chloride antitumor activity |
| title | Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor Agents |
| title_full | Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor Agents |
| title_fullStr | Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor Agents |
| title_full_unstemmed | Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor Agents |
| title_short | Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor Agents |
| title_sort | synthesis of 2 phenylazonaphtho 1 8 ef 1 4 diazepines and 9 3 arylhydrazono pyrrolo 1 2 a perimidines as antitumor agents |
| topic | 1,8-diaminonaphthalene naphtho[1,8-ef][1,4]diazepines pyrrolo[1,2-a] perimidines hydrazonoyl chloride antitumor activity |
| url | http://www.mdpi.com/1420-3049/19/1/740 |
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