Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection.

Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection.

Angiotensin-converting enzyme 2 (ACE2) is the cell-surface receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While its central role in Coronavirus Disease 2019 (COVID-19) pathogenesis is indisputable, there remains significant debate regarding the role of this transmembrane...

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Bibliographic Details
Main Authors: Alan T Tang, David W Buchholz, Katherine M Szigety, Brian Imbiakha, Siqi Gao, Maxwell Frankfurter, Min Wang, Jisheng Yang, Peter Hewins, Patricia Mericko-Ishizuka, N Adrian Leu, Stephanie Sterling, Isaac A Monreal, Julie Sahler, Avery August, Xuming Zhu, Kellie A Jurado, Mingang Xu, Edward E Morrisey, Sarah E Millar, Hector C Aguilar, Mark L Kahn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-02-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001989

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