The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders
This comprehensive review article dives deep into the Golgi apparatus, an essential organelle in cellular biology. Beginning with its discovery during the 19th century until today’s recognition as an important contributor to cell function. We explore its unique organization and structure as well as...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/15/1972 |
| _version_ | 1827731343762522112 |
|---|---|
| author | Aurel George Mohan Bogdan Calenic Nicu Adrian Ghiurau Roxana-Maria Duncea-Borca Alexandra-Elena Constantinescu Ileana Constantinescu |
| author_facet | Aurel George Mohan Bogdan Calenic Nicu Adrian Ghiurau Roxana-Maria Duncea-Borca Alexandra-Elena Constantinescu Ileana Constantinescu |
| author_sort | Aurel George Mohan |
| collection | DOAJ |
| description | This comprehensive review article dives deep into the Golgi apparatus, an essential organelle in cellular biology. Beginning with its discovery during the 19th century until today’s recognition as an important contributor to cell function. We explore its unique organization and structure as well as its roles in protein processing, sorting, and lipid biogenesis, which play key roles in maintaining homeostasis in cellular biology. This article further explores Golgi biogenesis, exploring its intricate processes and dynamics that contribute to its formation and function. One key focus is its role in neurodegenerative diseases like Parkinson’s, where changes to the structure or function of the Golgi apparatus may lead to their onset or progression, emphasizing its key importance in neuronal health. At the same time, we examine the intriguing relationship between Golgi stress and endoplasmic reticulum (ER) stress, providing insights into their interplay as two major cellular stress response pathways. Such interdependence provides a greater understanding of cellular reactions to protein misfolding and accumulation, hallmark features of many neurodegenerative diseases. In summary, this review offers an exhaustive examination of the Golgi apparatus, from its historical background to its role in health and disease. Additionally, this examination emphasizes the necessity of further research in this field in order to develop targeted therapeutic approaches for Golgi dysfunction-associated conditions. Furthermore, its exploration is an example of scientific progress while simultaneously offering hope for developing innovative treatments for neurodegenerative disorders. |
| first_indexed | 2024-03-11T00:29:05Z |
| format | Article |
| id | doaj.art-1b3960f8d7764066a34075e39d8f14f4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T00:29:05Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1b3960f8d7764066a34075e39d8f14f42023-11-18T22:45:08ZengMDPI AGCells2073-44092023-07-011215197210.3390/cells12151972The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative DisordersAurel George Mohan0Bogdan Calenic1Nicu Adrian Ghiurau2Roxana-Maria Duncea-Borca3Alexandra-Elena Constantinescu4Ileana Constantinescu5Department of Neurosurgery, Bihor County Emergency Clinical Hospital, 410167 Oradea, RomaniaImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410610 Oradea, RomaniaForensic Medical Service, 140090 Alexandria, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaThis comprehensive review article dives deep into the Golgi apparatus, an essential organelle in cellular biology. Beginning with its discovery during the 19th century until today’s recognition as an important contributor to cell function. We explore its unique organization and structure as well as its roles in protein processing, sorting, and lipid biogenesis, which play key roles in maintaining homeostasis in cellular biology. This article further explores Golgi biogenesis, exploring its intricate processes and dynamics that contribute to its formation and function. One key focus is its role in neurodegenerative diseases like Parkinson’s, where changes to the structure or function of the Golgi apparatus may lead to their onset or progression, emphasizing its key importance in neuronal health. At the same time, we examine the intriguing relationship between Golgi stress and endoplasmic reticulum (ER) stress, providing insights into their interplay as two major cellular stress response pathways. Such interdependence provides a greater understanding of cellular reactions to protein misfolding and accumulation, hallmark features of many neurodegenerative diseases. In summary, this review offers an exhaustive examination of the Golgi apparatus, from its historical background to its role in health and disease. Additionally, this examination emphasizes the necessity of further research in this field in order to develop targeted therapeutic approaches for Golgi dysfunction-associated conditions. Furthermore, its exploration is an example of scientific progress while simultaneously offering hope for developing innovative treatments for neurodegenerative disorders.https://www.mdpi.com/2073-4409/12/15/1972Golgi apparatusneurodegenerative diseasesParkinson’s diseaseendoplasmic reticulum stressneurobiologyGolgi disfunction |
| spellingShingle | Aurel George Mohan Bogdan Calenic Nicu Adrian Ghiurau Roxana-Maria Duncea-Borca Alexandra-Elena Constantinescu Ileana Constantinescu The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders Cells Golgi apparatus neurodegenerative diseases Parkinson’s disease endoplasmic reticulum stress neurobiology Golgi disfunction |
| title | The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders |
| title_full | The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders |
| title_fullStr | The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders |
| title_full_unstemmed | The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders |
| title_short | The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders |
| title_sort | golgi apparatus a voyage through time structure function and implication in neurodegenerative disorders |
| topic | Golgi apparatus neurodegenerative diseases Parkinson’s disease endoplasmic reticulum stress neurobiology Golgi disfunction |
| url | https://www.mdpi.com/2073-4409/12/15/1972 |
| work_keys_str_mv | AT aurelgeorgemohan thegolgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT bogdancalenic thegolgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT nicuadrianghiurau thegolgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT roxanamariadunceaborca thegolgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT alexandraelenaconstantinescu thegolgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT ileanaconstantinescu thegolgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT aurelgeorgemohan golgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT bogdancalenic golgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT nicuadrianghiurau golgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT roxanamariadunceaborca golgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT alexandraelenaconstantinescu golgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders AT ileanaconstantinescu golgiapparatusavoyagethroughtimestructurefunctionandimplicationinneurodegenerativedisorders |