Synthesis and optimization of octavalent bolaamphiphile preparation with terminal D-mannose residues
In this article a scheme was proposed, and the synthesis of octavalent bolaamphiphile with terminal D-mannose residues was carried out. The technique of the laboratory synthesis of this compound was improved using optimisation of the key step of the compound synthesis and purification of the final c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2015-10-01
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| Series: | Тонкие химические технологии |
| Subjects: | |
| Online Access: | https://www.finechem-mirea.ru/jour/article/view/257 |
| _version_ | 1797882020447125504 |
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| author | V. B. Gostenin I. S. Shchelik Yu. L. Sebyakin |
| author_facet | V. B. Gostenin I. S. Shchelik Yu. L. Sebyakin |
| author_sort | V. B. Gostenin |
| collection | DOAJ |
| description | In this article a scheme was proposed, and the synthesis of octavalent bolaamphiphile with terminal D-mannose residues was carried out. The technique of the laboratory synthesis of this compound was improved using optimisation of the key step of the compound synthesis and purification of the final compound. All intermediate steps of the final compound synthesis were described in detail. The terminal D-mannose residues will allow binding with mannose-specific lectins, for example, on the surface of E. coli morbidising the gastrointestinal tract. The resulting compound can be used as a potential anti-adhesion agent to prevent the development of infectious diseases. |
| first_indexed | 2024-04-10T03:29:23Z |
| format | Article |
| id | doaj.art-1b399483446a4a37a1c0d0448fe4b7f0 |
| institution | Directory Open Access Journal |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| last_indexed | 2024-04-10T03:29:23Z |
| publishDate | 2015-10-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj.art-1b399483446a4a37a1c0d0448fe4b7f02023-03-13T07:25:36ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752015-10-011053943251Synthesis and optimization of octavalent bolaamphiphile preparation with terminal D-mannose residuesV. B. Gostenin0I. S. Shchelik1Yu. L. Sebyakin2M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571In this article a scheme was proposed, and the synthesis of octavalent bolaamphiphile with terminal D-mannose residues was carried out. The technique of the laboratory synthesis of this compound was improved using optimisation of the key step of the compound synthesis and purification of the final compound. All intermediate steps of the final compound synthesis were described in detail. The terminal D-mannose residues will allow binding with mannose-specific lectins, for example, on the surface of E. coli morbidising the gastrointestinal tract. The resulting compound can be used as a potential anti-adhesion agent to prevent the development of infectious diseases.https://www.finechem-mirea.ru/jour/article/view/257carbohydrate derivatives, bolaamphiphile, antiadhesion therapy. |
| spellingShingle | V. B. Gostenin I. S. Shchelik Yu. L. Sebyakin Synthesis and optimization of octavalent bolaamphiphile preparation with terminal D-mannose residues Тонкие химические технологии carbohydrate derivatives, bolaamphiphile, antiadhesion therapy. |
| title | Synthesis and optimization of octavalent bolaamphiphile preparation with terminal D-mannose residues |
| title_full | Synthesis and optimization of octavalent bolaamphiphile preparation with terminal D-mannose residues |
| title_fullStr | Synthesis and optimization of octavalent bolaamphiphile preparation with terminal D-mannose residues |
| title_full_unstemmed | Synthesis and optimization of octavalent bolaamphiphile preparation with terminal D-mannose residues |
| title_short | Synthesis and optimization of octavalent bolaamphiphile preparation with terminal D-mannose residues |
| title_sort | synthesis and optimization of octavalent bolaamphiphile preparation with terminal d mannose residues |
| topic | carbohydrate derivatives, bolaamphiphile, antiadhesion therapy. |
| url | https://www.finechem-mirea.ru/jour/article/view/257 |
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