HATRIC-based identification of receptors for orphan ligands
Technologies for identifying receptor-ligand pairs on living cells at physiological conditions remain scarce. Here, the authors develop a mass spectrometry-based ligand receptor capture technology that can identify receptors for a diverse range of ligands at physiological pH with as few as a million...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03936-z |
| _version_ | 1819195795197394944 |
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| author | Nadine Sobotzki Michael A. Schafroth Alina Rudnicka Anika Koetemann Florian Marty Sandra Goetze Yohei Yamauchi Erick M. Carreira Bernd Wollscheid |
| author_facet | Nadine Sobotzki Michael A. Schafroth Alina Rudnicka Anika Koetemann Florian Marty Sandra Goetze Yohei Yamauchi Erick M. Carreira Bernd Wollscheid |
| author_sort | Nadine Sobotzki |
| collection | DOAJ |
| description | Technologies for identifying receptor-ligand pairs on living cells at physiological conditions remain scarce. Here, the authors develop a mass spectrometry-based ligand receptor capture technology that can identify receptors for a diverse range of ligands at physiological pH with as few as a million cells. |
| first_indexed | 2024-12-23T02:18:26Z |
| format | Article |
| id | doaj.art-1b3ff8e59603407da4c0f41e48155ad3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:18:26Z |
| publishDate | 2018-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1b3ff8e59603407da4c0f41e48155ad32022-12-21T18:03:37ZengNature PortfolioNature Communications2041-17232018-04-01911810.1038/s41467-018-03936-zHATRIC-based identification of receptors for orphan ligandsNadine Sobotzki0Michael A. Schafroth1Alina Rudnicka2Anika Koetemann3Florian Marty4Sandra Goetze5Yohei Yamauchi6Erick M. Carreira7Bernd Wollscheid8Department of Health Sciences and Technology & Institute of Molecular Systems Biology & BioMedical Proteomics Platform (BMPP), ETH ZurichDepartment of Chemistry and Applied Biosciences, Laboratory of Organic Chemistry, ETH ZürichUniversity of Zurich, Institute of Molecular Life SciencesDepartment of Health Sciences and Technology & Institute of Molecular Systems Biology & BioMedical Proteomics Platform (BMPP), ETH ZurichDualsystems Biotech AGDepartment of Health Sciences and Technology & Institute of Molecular Systems Biology & BioMedical Proteomics Platform (BMPP), ETH ZurichSchool of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, University WalkDepartment of Chemistry and Applied Biosciences, Laboratory of Organic Chemistry, ETH ZürichDepartment of Health Sciences and Technology & Institute of Molecular Systems Biology & BioMedical Proteomics Platform (BMPP), ETH ZurichTechnologies for identifying receptor-ligand pairs on living cells at physiological conditions remain scarce. Here, the authors develop a mass spectrometry-based ligand receptor capture technology that can identify receptors for a diverse range of ligands at physiological pH with as few as a million cells.https://doi.org/10.1038/s41467-018-03936-z |
| spellingShingle | Nadine Sobotzki Michael A. Schafroth Alina Rudnicka Anika Koetemann Florian Marty Sandra Goetze Yohei Yamauchi Erick M. Carreira Bernd Wollscheid HATRIC-based identification of receptors for orphan ligands Nature Communications |
| title | HATRIC-based identification of receptors for orphan ligands |
| title_full | HATRIC-based identification of receptors for orphan ligands |
| title_fullStr | HATRIC-based identification of receptors for orphan ligands |
| title_full_unstemmed | HATRIC-based identification of receptors for orphan ligands |
| title_short | HATRIC-based identification of receptors for orphan ligands |
| title_sort | hatric based identification of receptors for orphan ligands |
| url | https://doi.org/10.1038/s41467-018-03936-z |
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