Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications
Polymer nanoparticles doped with fluorescent molecules are widely applied for biological assays, local temperature measurements, and other bioimaging applications, overcoming several critical drawbacks, such as dye toxicity, increased water solubility, and allowing imaging of dyes/drug delivery in w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/12/3437 |
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| author | Frederico Duarte Cristián Cuerva Carlos Fernández-Lodeiro Javier Fernández-Lodeiro Raquel Jiménez Mercedes Cano Carlos Lodeiro |
| author_facet | Frederico Duarte Cristián Cuerva Carlos Fernández-Lodeiro Javier Fernández-Lodeiro Raquel Jiménez Mercedes Cano Carlos Lodeiro |
| author_sort | Frederico Duarte |
| collection | DOAJ |
| description | Polymer nanoparticles doped with fluorescent molecules are widely applied for biological assays, local temperature measurements, and other bioimaging applications, overcoming several critical drawbacks, such as dye toxicity, increased water solubility, and allowing imaging of dyes/drug delivery in water. In this work, some polymethylmethacrylate (PMMA), polyvinylpyrrolidone (PVP) and poly(styrene-butadiene-styrene) (SBS) based micro and nanoparticles with an average size of about 200 nm and encapsulating B(III) compounds have been prepared via the reprecipitation method by using tetrahydrofuran as the oil phase and water. The compounds are highly hydrophobic, but their encapsulation into a polymer matrix allows obtaining stable colloidal dispersions in water (3.39 µM) that maintain the photophysical behavior of these dyes. Although thermally activated non-radiative processes occur by increasing temperature from 25 to 80 °C, the colloidal suspension of the B(III) particles continues to emit greenish light (λ = 509 nm) at high temperatures. When samples are cooling back to room temperature, the emission is restored, being reversible. A probe of concept drug delivery study was conducted using coumarin 6 as a prototype of a hydrophobic drug. |
| first_indexed | 2024-03-10T03:25:05Z |
| format | Article |
| id | doaj.art-1b42721a43834c21a7828ca1e664bfdc |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:25:05Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-1b42721a43834c21a7828ca1e664bfdc2023-11-23T09:52:36ZengMDPI AGNanomaterials2079-49912021-12-011112343710.3390/nano11123437Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent ApplicationsFrederico Duarte0Cristián Cuerva1Carlos Fernández-Lodeiro2Javier Fernández-Lodeiro3Raquel Jiménez4Mercedes Cano5Carlos Lodeiro6BIOSCOPE Research Group, LAQV@REQUIMTE Chemistry Department, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, PortugalBIOSCOPE Research Group, LAQV@REQUIMTE Chemistry Department, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, PortugalCINBIO, Departamento de Química Física, Campus Universitario Lagoas Marcosende, Universidade de Vigo, 36310 Vigo, SpainBIOSCOPE Research Group, LAQV@REQUIMTE Chemistry Department, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, PortugalMatMoPol Research Group, Department of Inorganic Chemistry, Complutense University of Madrid, Ciudad Universitaria, 28040 Madrid, SpainMatMoPol Research Group, Department of Inorganic Chemistry, Complutense University of Madrid, Ciudad Universitaria, 28040 Madrid, SpainBIOSCOPE Research Group, LAQV@REQUIMTE Chemistry Department, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, PortugalPolymer nanoparticles doped with fluorescent molecules are widely applied for biological assays, local temperature measurements, and other bioimaging applications, overcoming several critical drawbacks, such as dye toxicity, increased water solubility, and allowing imaging of dyes/drug delivery in water. In this work, some polymethylmethacrylate (PMMA), polyvinylpyrrolidone (PVP) and poly(styrene-butadiene-styrene) (SBS) based micro and nanoparticles with an average size of about 200 nm and encapsulating B(III) compounds have been prepared via the reprecipitation method by using tetrahydrofuran as the oil phase and water. The compounds are highly hydrophobic, but their encapsulation into a polymer matrix allows obtaining stable colloidal dispersions in water (3.39 µM) that maintain the photophysical behavior of these dyes. Although thermally activated non-radiative processes occur by increasing temperature from 25 to 80 °C, the colloidal suspension of the B(III) particles continues to emit greenish light (λ = 509 nm) at high temperatures. When samples are cooling back to room temperature, the emission is restored, being reversible. A probe of concept drug delivery study was conducted using coumarin 6 as a prototype of a hydrophobic drug.https://www.mdpi.com/2079-4991/11/12/3437organoboranespolymer nanoparticlesdrug deliverytemperature sensors |
| spellingShingle | Frederico Duarte Cristián Cuerva Carlos Fernández-Lodeiro Javier Fernández-Lodeiro Raquel Jiménez Mercedes Cano Carlos Lodeiro Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications Nanomaterials organoboranes polymer nanoparticles drug delivery temperature sensors |
| title | Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications |
| title_full | Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications |
| title_fullStr | Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications |
| title_full_unstemmed | Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications |
| title_short | Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications |
| title_sort | polymer micro and nanoparticles containing b iii compounds as emissive soft materials for cargo encapsulation and temperature dependent applications |
| topic | organoboranes polymer nanoparticles drug delivery temperature sensors |
| url | https://www.mdpi.com/2079-4991/11/12/3437 |
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