Effects of medium-chain triglycerides on gluconeogenesis and ureagenesis in weaned rats fed a high fat diet
We explored the effects of Medium-chain triglycerides (MCT) on gluconeogenesis and ureagenesis in the liver of weaned male rats fed high fat, carbohydrate-free diets. The rats of three experimental groups and control were fed for 10 days. The diets were high fat, carbohydrate-free diets consisting e...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-12-01
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| Series: | Journal of Nutrition & Intermediary Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352385915000055 |
| _version_ | 1831694007122526208 |
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| author | Chitose Sugiyama Kamrun Nahar Akter Saho Morishita Ayako Miura Sachiko Takase |
| author_facet | Chitose Sugiyama Kamrun Nahar Akter Saho Morishita Ayako Miura Sachiko Takase |
| author_sort | Chitose Sugiyama |
| collection | DOAJ |
| description | We explored the effects of Medium-chain triglycerides (MCT) on gluconeogenesis and ureagenesis in the liver of weaned male rats fed high fat, carbohydrate-free diets. The rats of three experimental groups and control were fed for 10 days. The diets were high fat, carbohydrate-free diets consisting either of a corn oil or MCT, and high protein carbohydrate-free diet and a control (high carbohydrate) diet. The hepatic glucose-6-phosphatase (G6Pase) activity increased in the experimental groups. Despite the elevated G6Pase activity in these groups, hepatic activities of glutamic alanine transaminase (GAT), pyruvate carboxylase (PC) and arginase differed among the experimental groups. The HF-corn oil rats showed elevation of PC activity, but no elevation of GAT activity, and the lowest arginase activity among the three groups. The HF-MCT diet-fed rats showed higher GAT and arginase activities than the HF-corn oil group. In the HP diet-fed rats, GAT and arginase activities enhanced, PC did not. |
| first_indexed | 2024-12-20T12:26:38Z |
| format | Article |
| id | doaj.art-1b42ab3873c144319b92ff8558397c61 |
| institution | Directory Open Access Journal |
| issn | 2352-3859 |
| language | English |
| last_indexed | 2024-12-20T12:26:38Z |
| publishDate | 2015-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Nutrition & Intermediary Metabolism |
| spelling | doaj.art-1b42ab3873c144319b92ff8558397c612022-12-21T19:40:50ZengElsevierJournal of Nutrition & Intermediary Metabolism2352-38592015-12-0123656810.1016/j.jnim.2015.07.001Effects of medium-chain triglycerides on gluconeogenesis and ureagenesis in weaned rats fed a high fat dietChitose Sugiyama0Kamrun Nahar Akter1Saho Morishita2Ayako Miura3Sachiko Takase4Department of Health and Nutritional Sciences, Graduate School of Health Sciences, Hamamatsu University, Hamamatsu, JapanDepartment of Health and Nutritional Sciences, Graduate School of Health Sciences, Hamamatsu University, Hamamatsu, JapanDepartment of Health and Nutritional Sciences, Faculty of Health Promotional Sciences, Hamamatsu University, Hamamatsu, JapanDepartment of Health and Nutritional Sciences, Faculty of Health Promotional Sciences, Hamamatsu University, Hamamatsu, JapanDepartment of Health and Nutritional Sciences, Graduate School of Health Sciences, Hamamatsu University, Hamamatsu, JapanWe explored the effects of Medium-chain triglycerides (MCT) on gluconeogenesis and ureagenesis in the liver of weaned male rats fed high fat, carbohydrate-free diets. The rats of three experimental groups and control were fed for 10 days. The diets were high fat, carbohydrate-free diets consisting either of a corn oil or MCT, and high protein carbohydrate-free diet and a control (high carbohydrate) diet. The hepatic glucose-6-phosphatase (G6Pase) activity increased in the experimental groups. Despite the elevated G6Pase activity in these groups, hepatic activities of glutamic alanine transaminase (GAT), pyruvate carboxylase (PC) and arginase differed among the experimental groups. The HF-corn oil rats showed elevation of PC activity, but no elevation of GAT activity, and the lowest arginase activity among the three groups. The HF-MCT diet-fed rats showed higher GAT and arginase activities than the HF-corn oil group. In the HP diet-fed rats, GAT and arginase activities enhanced, PC did not.http://www.sciencedirect.com/science/article/pii/S2352385915000055Medium-chain triglyceidesGlucose-6-phosphataseGlutamic alanine transaminasePyruvate carboxylaseArginase |
| spellingShingle | Chitose Sugiyama Kamrun Nahar Akter Saho Morishita Ayako Miura Sachiko Takase Effects of medium-chain triglycerides on gluconeogenesis and ureagenesis in weaned rats fed a high fat diet Journal of Nutrition & Intermediary Metabolism Medium-chain triglyceides Glucose-6-phosphatase Glutamic alanine transaminase Pyruvate carboxylase Arginase |
| title | Effects of medium-chain triglycerides on gluconeogenesis and ureagenesis in weaned rats fed a high fat diet |
| title_full | Effects of medium-chain triglycerides on gluconeogenesis and ureagenesis in weaned rats fed a high fat diet |
| title_fullStr | Effects of medium-chain triglycerides on gluconeogenesis and ureagenesis in weaned rats fed a high fat diet |
| title_full_unstemmed | Effects of medium-chain triglycerides on gluconeogenesis and ureagenesis in weaned rats fed a high fat diet |
| title_short | Effects of medium-chain triglycerides on gluconeogenesis and ureagenesis in weaned rats fed a high fat diet |
| title_sort | effects of medium chain triglycerides on gluconeogenesis and ureagenesis in weaned rats fed a high fat diet |
| topic | Medium-chain triglyceides Glucose-6-phosphatase Glutamic alanine transaminase Pyruvate carboxylase Arginase |
| url | http://www.sciencedirect.com/science/article/pii/S2352385915000055 |
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