Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc

Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc

IntroductionT cell expressed CD27 provides costimulation upon binding to inducible membrane expressed trimeric CD70 and is required for protective CD8 T cell responses. CD27 agonists could therefore be used to bolster cellular vaccines and anti-tumour immune responses. To date, clinical development...

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Bibliographic Details
Main Authors: Osman Dadas, Joel D. Allen, Sarah L. Buchan, Jinny Kim, H. T. Claude Chan, C. Ian Mockridge, Patrick J. Duriez, Anne Rogel, Max Crispin, Aymen Al-Shamkhani
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
CD27
TNFRSF
costimulation
T cells
cancer
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252274/full

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