Catalpol Attenuates Pulmonary Fibrosis by Inhibiting Ang II/AT1 and TGF-β/Smad-Mediated Epithelial Mesenchymal Transition

Catalpol Attenuates Pulmonary Fibrosis by Inhibiting Ang II/AT1 and TGF-β/Smad-Mediated Epithelial Mesenchymal Transition

BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive and devastating chronic lung condition affecting over 3 million people worldwide with a high mortality rate and there are no effective drugs. Angiotensin II (Ang II), as a major effector peptide of the renin angiotensin aldosterone syste...

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Bibliographic Details
Main Authors:	Qun Yu, Dewei Zhu, Yang Zou, Kai Wang, Peili Rao, Yunhui Shen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Series:	Frontiers in Medicine
Subjects:	idiopathic pulmonary fibrosis Ang II TGF-β/Smad signaling pathway EMT catalpol
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2022.878601/full

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