Of mice and men and women: Sexual dimorphism of the gut microbiome
The gut microbiome plays a critical role in developing and educating our immune system. Therefore, its now well-established role in autoimmunity and immune disorders is in some ways not surprising. However, it is well-documented in the literature that there is a female predisposition to autoimmune d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2021-12-01
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| Series: | International Journal of Women's Dermatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352647521001295 |
| _version_ | 1818907699439468544 |
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| author | Jean S. McGee, MD, PhD Curtis Huttenhower, PhD |
| author_facet | Jean S. McGee, MD, PhD Curtis Huttenhower, PhD |
| author_sort | Jean S. McGee, MD, PhD |
| collection | DOAJ |
| description | The gut microbiome plays a critical role in developing and educating our immune system. Therefore, its now well-established role in autoimmunity and immune disorders is in some ways not surprising. However, it is well-documented in the literature that there is a female predisposition to autoimmune disorders, while sexual dimorphisms in the human microbiome have been confined largely to areas outside of the gut. Herein, we will review the evidence of sexual dimorphism in the gut microbiome in both mice and humans, how this differs in animal models versus humans, and how such dimorphisms may be established and influenced by both host and environmental factors. We will conclude with a discussion on how these aspects of the gut microbiome may contribute to both the study and pathogenesis of gender-specific autoimmunity and immune disorders. |
| first_indexed | 2024-12-19T21:59:16Z |
| format | Article |
| id | doaj.art-1b472faef6b042108f8033745dae82ab |
| institution | Directory Open Access Journal |
| issn | 2352-6475 |
| language | English |
| last_indexed | 2024-12-19T21:59:16Z |
| publishDate | 2021-12-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | International Journal of Women's Dermatology |
| spelling | doaj.art-1b472faef6b042108f8033745dae82ab2022-12-21T20:04:11ZengWolters KluwerInternational Journal of Women's Dermatology2352-64752021-12-0175533538Of mice and men and women: Sexual dimorphism of the gut microbiomeJean S. McGee, MD, PhD0Curtis Huttenhower, PhD1Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Corresponding author.Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, MassachusettsThe gut microbiome plays a critical role in developing and educating our immune system. Therefore, its now well-established role in autoimmunity and immune disorders is in some ways not surprising. However, it is well-documented in the literature that there is a female predisposition to autoimmune disorders, while sexual dimorphisms in the human microbiome have been confined largely to areas outside of the gut. Herein, we will review the evidence of sexual dimorphism in the gut microbiome in both mice and humans, how this differs in animal models versus humans, and how such dimorphisms may be established and influenced by both host and environmental factors. We will conclude with a discussion on how these aspects of the gut microbiome may contribute to both the study and pathogenesis of gender-specific autoimmunity and immune disorders.http://www.sciencedirect.com/science/article/pii/S2352647521001295Sexual dimorphismgut microbiomegendersex hormonesdietmice |
| spellingShingle | Jean S. McGee, MD, PhD Curtis Huttenhower, PhD Of mice and men and women: Sexual dimorphism of the gut microbiome International Journal of Women's Dermatology Sexual dimorphism gut microbiome gender sex hormones diet mice |
| title | Of mice and men and women: Sexual dimorphism of the gut microbiome |
| title_full | Of mice and men and women: Sexual dimorphism of the gut microbiome |
| title_fullStr | Of mice and men and women: Sexual dimorphism of the gut microbiome |
| title_full_unstemmed | Of mice and men and women: Sexual dimorphism of the gut microbiome |
| title_short | Of mice and men and women: Sexual dimorphism of the gut microbiome |
| title_sort | of mice and men and women sexual dimorphism of the gut microbiome |
| topic | Sexual dimorphism gut microbiome gender sex hormones diet mice |
| url | http://www.sciencedirect.com/science/article/pii/S2352647521001295 |
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