Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate
The aim of present study was to prepared ocular in-situ gel to increase the residence time of drug in cornea for improvement of ocular bioavailability of drug. In situ gel of Loteprednol etabonate was prepared by using carobopol 940 and different grades of HPMC in different ratios by pH triggered me...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Creative Pharma Assent
2021-06-01
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| Series: | Journal of Applied Pharmaceutical Research |
| Subjects: | |
| Online Access: | https://japtronline.com/index.php/joapr/article/view/220 |
| _version_ | 1798024319442354176 |
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| author | Shaikh Shoaeba Desai Sharav Hitesh Jain Asit Sahu D. B. Meshram |
| author_facet | Shaikh Shoaeba Desai Sharav Hitesh Jain Asit Sahu D. B. Meshram |
| author_sort | Shaikh Shoaeba |
| collection | DOAJ |
| description | The aim of present study was to prepared ocular in-situ gel to increase the residence time of drug in cornea for improvement of ocular bioavailability of drug. In situ gel of Loteprednol etabonate was prepared by using carobopol 940 and different grades of HPMC in different ratios by pH triggered method. The prepared in situ gels were evaluated for pH, drug content, viscosity, gelling time, gelling strength spreadability and sterility testing. In vitro drug release study was carried by using diffusion cell with dialysis membrane. The drug content and pH of the formulation were found to be satisfactory. The gelling strength was found to be in the range of 34 seconds to 91 seconds. The viscosity and spredability of the formulations were found to be satisfactory. Formulation F5 containing 0.3 % carobopol 940 and 0.6 % HPMC K4M showed highest drug release of 80.30 %. The developed formulations showed sustained release of drug up to 8 hrs. From in-vitro drug release studies, it could be concluded that the developed in-situ gelling systems were thus a better alternative to conventional eye drops. |
| first_indexed | 2024-04-11T18:00:34Z |
| format | Article |
| id | doaj.art-1b492aa03ab34fa59ee052f788557d2c |
| institution | Directory Open Access Journal |
| issn | 2348-0335 |
| language | English |
| last_indexed | 2024-04-11T18:00:34Z |
| publishDate | 2021-06-01 |
| publisher | Creative Pharma Assent |
| record_format | Article |
| series | Journal of Applied Pharmaceutical Research |
| spelling | doaj.art-1b492aa03ab34fa59ee052f788557d2c2022-12-22T04:10:32ZengCreative Pharma AssentJournal of Applied Pharmaceutical Research2348-03352021-06-0192252910.18231/j.joapr.2021.25.29221Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonateShaikh Shoaeba0Desai Sharav1Hitesh Jain2Asit Sahu3D. B. Meshram4Pioneer Pharmacy Degree College, Vadodara, GujaratPioneer Pharmacy Degree College, Vadodara, GujaratPioneer Pharmacy Degree College, Vadodara, GujaratPioneer Pharmacy Degree College, Vadodara, GujaratPioneer Pharmacy Degree College, Vadodara, GujaratThe aim of present study was to prepared ocular in-situ gel to increase the residence time of drug in cornea for improvement of ocular bioavailability of drug. In situ gel of Loteprednol etabonate was prepared by using carobopol 940 and different grades of HPMC in different ratios by pH triggered method. The prepared in situ gels were evaluated for pH, drug content, viscosity, gelling time, gelling strength spreadability and sterility testing. In vitro drug release study was carried by using diffusion cell with dialysis membrane. The drug content and pH of the formulation were found to be satisfactory. The gelling strength was found to be in the range of 34 seconds to 91 seconds. The viscosity and spredability of the formulations were found to be satisfactory. Formulation F5 containing 0.3 % carobopol 940 and 0.6 % HPMC K4M showed highest drug release of 80.30 %. The developed formulations showed sustained release of drug up to 8 hrs. From in-vitro drug release studies, it could be concluded that the developed in-situ gelling systems were thus a better alternative to conventional eye drops.https://japtronline.com/index.php/joapr/article/view/220occularin situ gelph triggeredloteprednol etabonate |
| spellingShingle | Shaikh Shoaeba Desai Sharav Hitesh Jain Asit Sahu D. B. Meshram Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate Journal of Applied Pharmaceutical Research occular in situ gel ph triggered loteprednol etabonate |
| title | Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate |
| title_full | Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate |
| title_fullStr | Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate |
| title_full_unstemmed | Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate |
| title_short | Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate |
| title_sort | formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate |
| topic | occular in situ gel ph triggered loteprednol etabonate |
| url | https://japtronline.com/index.php/joapr/article/view/220 |
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