Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signaling pathway

Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signaling pathway

Abstract Background Myocardial ischemia-reperfusion injury (MIRI) is one of the main reasons for poor prognosis in patients with ischemic cardiomyopathy (ICM). To date, the mechanism remains unknown. As members of the silent information regulator 2 (SIR2) family, both SIRT1 and SIRT3 have been shown...

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Bibliographic Details
Main Authors: Yunfei Liao, Ben Ke, Xiaoyan Long, Jianjun Xu, Yongbing Wu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Cardiovascular Disorders
Subjects:
SIRT1-SIRT3 axis
Ferroptosis
Mitophagy
PINK1/Parkin signaling pathway
Myocardial ischemia-reperfusion injury
Online Access:https://doi.org/10.1186/s12872-023-03603-2

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