A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence.
Successful replication within an infected host and successful transmission between hosts are key to the continued spread of most pathogens. Competing selection pressures exerted at these different scales can lead to evolutionary trade-offs between the determinants of fitness within and between hosts...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC3605121?pdf=render |
| _version_ | 1818961364904837120 |
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| author | Andreas Handel Justin Brown David Stallknecht Pejman Rohani |
| author_facet | Andreas Handel Justin Brown David Stallknecht Pejman Rohani |
| author_sort | Andreas Handel |
| collection | DOAJ |
| description | Successful replication within an infected host and successful transmission between hosts are key to the continued spread of most pathogens. Competing selection pressures exerted at these different scales can lead to evolutionary trade-offs between the determinants of fitness within and between hosts. Here, we examine such a trade-off in the context of influenza A viruses and the differential pressures exerted by temperature-dependent virus persistence. For a panel of avian influenza A virus strains, we find evidence for a trade-off between the persistence at high versus low temperatures. Combining a within-host model of influenza infection dynamics with a between-host transmission model, we study how such a trade-off affects virus fitness on the host population level. We show that conclusions regarding overall fitness are affected by the type of link assumed between the within- and between-host levels and the main route of transmission (direct or environmental). The relative importance of virulence and immune response mediated virus clearance are also found to influence the fitness impacts of virus persistence at low versus high temperatures. Based on our results, we predict that if transmission occurs mainly directly and scales linearly with virus load, and virulence or immune responses are negligible, the evolutionary pressure for influenza viruses to evolve toward good persistence at high within-host temperatures dominates. For all other scenarios, influenza viruses with good environmental persistence at low temperatures seem to be favored. |
| first_indexed | 2024-12-20T12:12:16Z |
| format | Article |
| id | doaj.art-1b4d2847099c4393822eced24f1be811 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-20T12:12:16Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-1b4d2847099c4393822eced24f1be8112022-12-21T19:41:14ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582013-01-0193e100298910.1371/journal.pcbi.1002989A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence.Andreas HandelJustin BrownDavid StallknechtPejman RohaniSuccessful replication within an infected host and successful transmission between hosts are key to the continued spread of most pathogens. Competing selection pressures exerted at these different scales can lead to evolutionary trade-offs between the determinants of fitness within and between hosts. Here, we examine such a trade-off in the context of influenza A viruses and the differential pressures exerted by temperature-dependent virus persistence. For a panel of avian influenza A virus strains, we find evidence for a trade-off between the persistence at high versus low temperatures. Combining a within-host model of influenza infection dynamics with a between-host transmission model, we study how such a trade-off affects virus fitness on the host population level. We show that conclusions regarding overall fitness are affected by the type of link assumed between the within- and between-host levels and the main route of transmission (direct or environmental). The relative importance of virulence and immune response mediated virus clearance are also found to influence the fitness impacts of virus persistence at low versus high temperatures. Based on our results, we predict that if transmission occurs mainly directly and scales linearly with virus load, and virulence or immune responses are negligible, the evolutionary pressure for influenza viruses to evolve toward good persistence at high within-host temperatures dominates. For all other scenarios, influenza viruses with good environmental persistence at low temperatures seem to be favored.http://europepmc.org/articles/PMC3605121?pdf=render |
| spellingShingle | Andreas Handel Justin Brown David Stallknecht Pejman Rohani A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence. PLoS Computational Biology |
| title | A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence. |
| title_full | A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence. |
| title_fullStr | A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence. |
| title_full_unstemmed | A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence. |
| title_short | A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence. |
| title_sort | multi scale analysis of influenza a virus fitness trade offs due to temperature dependent virus persistence |
| url | http://europepmc.org/articles/PMC3605121?pdf=render |
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