The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease
Abstract Heated tobacco products (HTPs) have emerged as novel alternatives to conventional cigarettes (CCs), marketed by the tobacco industry as having a reduced potential for harm. Nevertheless, a significant dearth of information remains regarding the long-term effects of HTPs on the central nervo...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-50941-4 |
| _version_ | 1797363421489922048 |
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| author | Hidetada Yamada Yu Yamazaki Yoshiko Takebayashi Kyosuke Yazawa Miwako Sasanishi Atsuko Motoda Masahiro Nakamori Hiroyuki Morino Tetsuya Takahashi Hirofumi Maruyama |
| author_facet | Hidetada Yamada Yu Yamazaki Yoshiko Takebayashi Kyosuke Yazawa Miwako Sasanishi Atsuko Motoda Masahiro Nakamori Hiroyuki Morino Tetsuya Takahashi Hirofumi Maruyama |
| author_sort | Hidetada Yamada |
| collection | DOAJ |
| description | Abstract Heated tobacco products (HTPs) have emerged as novel alternatives to conventional cigarettes (CCs), marketed by the tobacco industry as having a reduced potential for harm. Nevertheless, a significant dearth of information remains regarding the long-term effects of HTPs on the central nervous system (CNS). Here, we sought to shed light on the repercussions of prolonged exposure to HTPs on the CNS, employing a mouse model mimicking prodromal Alzheimer's disease (AD). Our study entailed subjecting App knock-in mice to 16 weeks of HTP exposure, administered 5 days per week, with serum cotinine concentration serving as confirmation of HTP exposure within this model. Histological analysis, aimed at assessing amyloid pathology, unveiled a minimal impact attributable to HTPs. However, exploration of differentially expressed genes in the cerebral cortex, using unadjusted p values, indicated an association between HTP exposure and non-inflammatory pathways, specifically linked to neurohypophyseal and neuropeptide hormone activity within the CNS. Of note, similar results have already been observed after exposure to CCs in vivo. Our study not only contributes insights into the potential non-inflammatory effects of HTPs within the context of AD pathogenesis but also underscores the significance of continued research to comprehend the full scope of their impact on the CNS. |
| first_indexed | 2024-03-08T16:21:08Z |
| format | Article |
| id | doaj.art-1b4ea40d4a684312affbdb5d53955478 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T16:21:08Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1b4ea40d4a684312affbdb5d539554782024-01-07T12:21:38ZengNature PortfolioScientific Reports2045-23222024-01-0114111210.1038/s41598-023-50941-4The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's diseaseHidetada Yamada0Yu Yamazaki1Yoshiko Takebayashi2Kyosuke Yazawa3Miwako Sasanishi4Atsuko Motoda5Masahiro Nakamori6Hiroyuki Morino7Tetsuya Takahashi8Hirofumi Maruyama9Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical SciencesDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical SciencesDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical SciencesDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical SciencesDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical SciencesDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical SciencesDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical SciencesDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical SciencesDepartment of Rehabilitation, Faculty of Rehabilitation, Hiroshima International UniversityDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical SciencesAbstract Heated tobacco products (HTPs) have emerged as novel alternatives to conventional cigarettes (CCs), marketed by the tobacco industry as having a reduced potential for harm. Nevertheless, a significant dearth of information remains regarding the long-term effects of HTPs on the central nervous system (CNS). Here, we sought to shed light on the repercussions of prolonged exposure to HTPs on the CNS, employing a mouse model mimicking prodromal Alzheimer's disease (AD). Our study entailed subjecting App knock-in mice to 16 weeks of HTP exposure, administered 5 days per week, with serum cotinine concentration serving as confirmation of HTP exposure within this model. Histological analysis, aimed at assessing amyloid pathology, unveiled a minimal impact attributable to HTPs. However, exploration of differentially expressed genes in the cerebral cortex, using unadjusted p values, indicated an association between HTP exposure and non-inflammatory pathways, specifically linked to neurohypophyseal and neuropeptide hormone activity within the CNS. Of note, similar results have already been observed after exposure to CCs in vivo. Our study not only contributes insights into the potential non-inflammatory effects of HTPs within the context of AD pathogenesis but also underscores the significance of continued research to comprehend the full scope of their impact on the CNS.https://doi.org/10.1038/s41598-023-50941-4 |
| spellingShingle | Hidetada Yamada Yu Yamazaki Yoshiko Takebayashi Kyosuke Yazawa Miwako Sasanishi Atsuko Motoda Masahiro Nakamori Hiroyuki Morino Tetsuya Takahashi Hirofumi Maruyama The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease Scientific Reports |
| title | The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease |
| title_full | The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease |
| title_fullStr | The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease |
| title_full_unstemmed | The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease |
| title_short | The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease |
| title_sort | long term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal alzheimer s disease |
| url | https://doi.org/10.1038/s41598-023-50941-4 |
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