Right colon cancer: The influence of specific location on recurrence and survival
Aim: This study aimed to investigate whether the site of the tumour within the right colon affects survival in patients who underwent right colectomy for colon cancer. Methods: An observational retrospective longitudinal study was performed in patients who underwent right colectomy for non-metastati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S246829422300045X |
| _version_ | 1797732840525266944 |
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| author | Ana Sofia Cavadas Eduarda Gonçalves Carlos Costa Pereira Jorge Rodrigues Joaquim Costa Pereira |
| author_facet | Ana Sofia Cavadas Eduarda Gonçalves Carlos Costa Pereira Jorge Rodrigues Joaquim Costa Pereira |
| author_sort | Ana Sofia Cavadas |
| collection | DOAJ |
| description | Aim: This study aimed to investigate whether the site of the tumour within the right colon affects survival in patients who underwent right colectomy for colon cancer. Methods: An observational retrospective longitudinal study was performed in patients who underwent right colectomy for non-metastatic, invasive right-sided colon cancer. Patients were categorized into two groups based on tumour location: (i) caecum and ascending colon; (ii) hepatic flexure and proximal transverse colon. Demographic and clinical features were characterized, and a survival analysis was performed. Results: Of the 198 patients enroled in the study, 134 (67.8%) had caecal or ascending colon cancer and 64 (32.3%) had hepatic flexure or transverse colon cancer. Seventy (35.4%) were female and the mean age at the time of surgery was 71.6 (SD 11.4). The groups were comparable with respect to the number of lymph nodes sampled, the pTNM stage, the histological differentiation grade and the likelihood of patients receiving adjuvant chemotherapy. Recurrence rate was nearly twice as high in the hepatic flexure and proximal transverse colon group (12.5% vs 6.7%), but this difference was not statistically significant (p = 0.174). Kaplan-Meier analysis showed no differences in disease-free (p = 0.255) and overall survival (p = 0.258) between the groups. Conclusion: In our population, specific location of right-sided colon cancers does not appear to have an influence on survival. Further investigation is needed to determine if tumour subsite has an impact on the recurrence rate, and whether it should be considered in defining prognosis and treatment. |
| first_indexed | 2024-03-12T12:20:20Z |
| format | Article |
| id | doaj.art-1b4ee66600714c56a3fee98d364e188a |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-03-12T12:20:20Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-1b4ee66600714c56a3fee98d364e188a2023-08-30T05:54:22ZengElsevierCancer Treatment and Research Communications2468-29422023-01-0136100724Right colon cancer: The influence of specific location on recurrence and survivalAna Sofia Cavadas0Eduarda Gonçalves1Carlos Costa Pereira2Jorge Rodrigues3Joaquim Costa Pereira4Hospital de Braga, Sete Fontes - São Victor, Braga 4710-243 Portugal; Corresponding author.Hospital de Braga, Sete Fontes - São Victor, Braga 4710-243 PortugalHospital de Braga, Sete Fontes - São Victor, Braga 4710-243 PortugalHospital de Braga, Sete Fontes - São Victor, Braga 4710-243 PortugalHospital de Braga, Sete Fontes - São Victor, Braga 4710-243 Portugal; Escola de Medicina da Universidade do Minho, PortugalAim: This study aimed to investigate whether the site of the tumour within the right colon affects survival in patients who underwent right colectomy for colon cancer. Methods: An observational retrospective longitudinal study was performed in patients who underwent right colectomy for non-metastatic, invasive right-sided colon cancer. Patients were categorized into two groups based on tumour location: (i) caecum and ascending colon; (ii) hepatic flexure and proximal transverse colon. Demographic and clinical features were characterized, and a survival analysis was performed. Results: Of the 198 patients enroled in the study, 134 (67.8%) had caecal or ascending colon cancer and 64 (32.3%) had hepatic flexure or transverse colon cancer. Seventy (35.4%) were female and the mean age at the time of surgery was 71.6 (SD 11.4). The groups were comparable with respect to the number of lymph nodes sampled, the pTNM stage, the histological differentiation grade and the likelihood of patients receiving adjuvant chemotherapy. Recurrence rate was nearly twice as high in the hepatic flexure and proximal transverse colon group (12.5% vs 6.7%), but this difference was not statistically significant (p = 0.174). Kaplan-Meier analysis showed no differences in disease-free (p = 0.255) and overall survival (p = 0.258) between the groups. Conclusion: In our population, specific location of right-sided colon cancers does not appear to have an influence on survival. Further investigation is needed to determine if tumour subsite has an impact on the recurrence rate, and whether it should be considered in defining prognosis and treatment.http://www.sciencedirect.com/science/article/pii/S246829422300045XColon cancerRight colon cancerTumor locationSurvivalRecurrence rate |
| spellingShingle | Ana Sofia Cavadas Eduarda Gonçalves Carlos Costa Pereira Jorge Rodrigues Joaquim Costa Pereira Right colon cancer: The influence of specific location on recurrence and survival Cancer Treatment and Research Communications Colon cancer Right colon cancer Tumor location Survival Recurrence rate |
| title | Right colon cancer: The influence of specific location on recurrence and survival |
| title_full | Right colon cancer: The influence of specific location on recurrence and survival |
| title_fullStr | Right colon cancer: The influence of specific location on recurrence and survival |
| title_full_unstemmed | Right colon cancer: The influence of specific location on recurrence and survival |
| title_short | Right colon cancer: The influence of specific location on recurrence and survival |
| title_sort | right colon cancer the influence of specific location on recurrence and survival |
| topic | Colon cancer Right colon cancer Tumor location Survival Recurrence rate |
| url | http://www.sciencedirect.com/science/article/pii/S246829422300045X |
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