Associations of infant nutrition with insulin resistance measures in early adulthood: evidence from the Barry-Caerphilly Growth (BCG) study.
Previous studies suggest that over-nutrition in early infancy may programme long-term susceptibility to insulin resistance.To assess the association of breast milk and quantity of infant formula and cows' milk intake during infancy with insulin resistance measures in early adulthood.Long-term f...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3313975?pdf=render |
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| author | Dylan M Williams Richard M Martin George Davey Smith K G M M Alberti Yoav Ben-Shlomo Anne McCarthy |
| author_facet | Dylan M Williams Richard M Martin George Davey Smith K G M M Alberti Yoav Ben-Shlomo Anne McCarthy |
| author_sort | Dylan M Williams |
| collection | DOAJ |
| description | Previous studies suggest that over-nutrition in early infancy may programme long-term susceptibility to insulin resistance.To assess the association of breast milk and quantity of infant formula and cows' milk intake during infancy with insulin resistance measures in early adulthood.Long-term follow-up of the Barry Caerphilly Growth cohort, into which mothers and their offspring had originally been randomly assigned, between 1972-1974, to receive milk supplementation or not. Participants were the offspring, aged 23-27 years at follow-up (n = 679). Breastfeeding and formula/cows' milk intake was recorded prospectively by nurses. The main outcomes were insulin sensitivity (ISI(0)) and insulin secretion (CIR(30)).573 (84%) individuals had valid glucose and insulin results and complete covariate information. There was little evidence of associations of breastfeeding versus any formula/cows' milk feeding or of increasing quartiles of formula/cows' milk consumption during infancy (<3 months) with any outcome measure in young adulthood. In fully adjusted models, the differences in outcomes between breastfeeding versus formula/cows' milk feeding at 3 months were: fasting glucose (-0.07 mmol/l; 95% CI: -0.19, 0.05); fasting insulin (8.0%; -8.7, 27.6); ISI(0) (-6.1%; -11.3, 12.1) and CIR(30) (3.8%; -19.0, 32.8). There was also little evidence that increasing intakes of formula/cows' milk at 3 months were associated with fasting glucose (increase per quartile of formula/cows' milk intake = 0.00 mmol/l; -0.03, 0.03); fasting insulin (0.8%; -3.2, 5.1); ISI (0) (-0.9%; -5.1, 3.5) and CIR(30) (-2.6%; -8.4, 3.6).We found no evidence that increasing consumption of formula/cows' milk in early infancy was associated with insulin resistance in young adulthood. |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T11:11:52Z |
| publishDate | 2012-01-01 |
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| spelling | doaj.art-1b4f26d8ba944d1f844c17476e8ba2842022-12-21T19:06:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3416110.1371/journal.pone.0034161Associations of infant nutrition with insulin resistance measures in early adulthood: evidence from the Barry-Caerphilly Growth (BCG) study.Dylan M WilliamsRichard M MartinGeorge Davey SmithK G M M AlbertiYoav Ben-ShlomoAnne McCarthyPrevious studies suggest that over-nutrition in early infancy may programme long-term susceptibility to insulin resistance.To assess the association of breast milk and quantity of infant formula and cows' milk intake during infancy with insulin resistance measures in early adulthood.Long-term follow-up of the Barry Caerphilly Growth cohort, into which mothers and their offspring had originally been randomly assigned, between 1972-1974, to receive milk supplementation or not. Participants were the offspring, aged 23-27 years at follow-up (n = 679). Breastfeeding and formula/cows' milk intake was recorded prospectively by nurses. The main outcomes were insulin sensitivity (ISI(0)) and insulin secretion (CIR(30)).573 (84%) individuals had valid glucose and insulin results and complete covariate information. There was little evidence of associations of breastfeeding versus any formula/cows' milk feeding or of increasing quartiles of formula/cows' milk consumption during infancy (<3 months) with any outcome measure in young adulthood. In fully adjusted models, the differences in outcomes between breastfeeding versus formula/cows' milk feeding at 3 months were: fasting glucose (-0.07 mmol/l; 95% CI: -0.19, 0.05); fasting insulin (8.0%; -8.7, 27.6); ISI(0) (-6.1%; -11.3, 12.1) and CIR(30) (3.8%; -19.0, 32.8). There was also little evidence that increasing intakes of formula/cows' milk at 3 months were associated with fasting glucose (increase per quartile of formula/cows' milk intake = 0.00 mmol/l; -0.03, 0.03); fasting insulin (0.8%; -3.2, 5.1); ISI (0) (-0.9%; -5.1, 3.5) and CIR(30) (-2.6%; -8.4, 3.6).We found no evidence that increasing consumption of formula/cows' milk in early infancy was associated with insulin resistance in young adulthood.http://europepmc.org/articles/PMC3313975?pdf=render |
| spellingShingle | Dylan M Williams Richard M Martin George Davey Smith K G M M Alberti Yoav Ben-Shlomo Anne McCarthy Associations of infant nutrition with insulin resistance measures in early adulthood: evidence from the Barry-Caerphilly Growth (BCG) study. PLoS ONE |
| title | Associations of infant nutrition with insulin resistance measures in early adulthood: evidence from the Barry-Caerphilly Growth (BCG) study. |
| title_full | Associations of infant nutrition with insulin resistance measures in early adulthood: evidence from the Barry-Caerphilly Growth (BCG) study. |
| title_fullStr | Associations of infant nutrition with insulin resistance measures in early adulthood: evidence from the Barry-Caerphilly Growth (BCG) study. |
| title_full_unstemmed | Associations of infant nutrition with insulin resistance measures in early adulthood: evidence from the Barry-Caerphilly Growth (BCG) study. |
| title_short | Associations of infant nutrition with insulin resistance measures in early adulthood: evidence from the Barry-Caerphilly Growth (BCG) study. |
| title_sort | associations of infant nutrition with insulin resistance measures in early adulthood evidence from the barry caerphilly growth bcg study |
| url | http://europepmc.org/articles/PMC3313975?pdf=render |
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