Inhibition of autophagy by CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR pathway contributes to ischemic postconditioning-induced neuroprotection against cerebral ischemia-reperfusion injury

Inhibition of autophagy by CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR pathway contributes to ischemic postconditioning-induced neuroprotection against cerebral ischemia-reperfusion injury

Abstract Cerebral ischemia, a common cerebrovascular disease, is characterized by functional deficits and apoptotic cell death. Autophagy, a type of programmed cell death, plays critical roles in controlling neuronal damage and metabolic homeostasis, and has been inextricably linked to cerebral isch...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Yuan Yao, Yingshi Ji, Jinghong Ren, Huanyu Liu, Rajesh Khanna, Li Sun
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: BMC 2021-08-01
Sarja:Molecular Brain
Aiheet:
Cerebral ischemia injury
Glutamate
CRMP2
Apoptosis
Autophagy
CaMKKβ/AMPK/mTOR pathway
Linkit:https://doi.org/10.1186/s13041-021-00836-0

Internet

https://doi.org/10.1186/s13041-021-00836-0

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