Role of EPAC1 in chronic pain
Chronic pain usually lasts over three months and commonly occurs in chronic diseases (cancer, arthritis, and diabetes), injuries (herniated discs, torn ligaments), and many major pain disorders (neuropathic pain, fibromyalgia, chronic headaches). Unfortunately, there is currently a lack of effective...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580824000098 |
| _version_ | 1797317102985543680 |
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| author | Chenlu Jiang Jiacheng Zhao Yihang Zhang Xiang Zhu |
| author_facet | Chenlu Jiang Jiacheng Zhao Yihang Zhang Xiang Zhu |
| author_sort | Chenlu Jiang |
| collection | DOAJ |
| description | Chronic pain usually lasts over three months and commonly occurs in chronic diseases (cancer, arthritis, and diabetes), injuries (herniated discs, torn ligaments), and many major pain disorders (neuropathic pain, fibromyalgia, chronic headaches). Unfortunately, there is currently a lack of effective treatments to help people with chronic pain to achieve complete relief. Therefore,it is particularly important to understand the mechanism of chronic pain and find new therapeutic targets. The exchange protein directly activated by cyclic adenosine monophosphate(cAMP) (EPAC) has been recognized for its functions in nerve regeneration, stimulating insulin release, controlling vascular pressure, and controlling other metabolic activities. In recent years, many studies have found that the subtype of EPAC, EPAC1 is involved in the regulation of neuroinflammation and plays a crucial role in the regulation of pain, which is expected to become a new therapeutic target for chronic pain. This article reviews the major contributions of EPAC1 in chronic pain. |
| first_indexed | 2024-03-08T03:30:01Z |
| format | Article |
| id | doaj.art-1b5219903f934da1b8ab775a44c4759d |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-03-08T03:30:01Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-1b5219903f934da1b8ab775a44c4759d2024-02-11T05:11:22ZengElsevierBiochemistry and Biophysics Reports2405-58082024-03-0137101645Role of EPAC1 in chronic painChenlu Jiang0Jiacheng Zhao1Yihang Zhang2Xiang Zhu3Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China; Medical School of Nantong University, Nantong, 226001, ChinaDepartment of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China; Medical School of Nantong University, Nantong, 226001, ChinaMedical School of Nantong University, Nantong, 226001, ChinaDepartment of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China; Corresponding author.Chronic pain usually lasts over three months and commonly occurs in chronic diseases (cancer, arthritis, and diabetes), injuries (herniated discs, torn ligaments), and many major pain disorders (neuropathic pain, fibromyalgia, chronic headaches). Unfortunately, there is currently a lack of effective treatments to help people with chronic pain to achieve complete relief. Therefore,it is particularly important to understand the mechanism of chronic pain and find new therapeutic targets. The exchange protein directly activated by cyclic adenosine monophosphate(cAMP) (EPAC) has been recognized for its functions in nerve regeneration, stimulating insulin release, controlling vascular pressure, and controlling other metabolic activities. In recent years, many studies have found that the subtype of EPAC, EPAC1 is involved in the regulation of neuroinflammation and plays a crucial role in the regulation of pain, which is expected to become a new therapeutic target for chronic pain. This article reviews the major contributions of EPAC1 in chronic pain.http://www.sciencedirect.com/science/article/pii/S2405580824000098EPAC1Chronic painNeuropathic painProtein kinaseIon channel |
| spellingShingle | Chenlu Jiang Jiacheng Zhao Yihang Zhang Xiang Zhu Role of EPAC1 in chronic pain Biochemistry and Biophysics Reports EPAC1 Chronic pain Neuropathic pain Protein kinase Ion channel |
| title | Role of EPAC1 in chronic pain |
| title_full | Role of EPAC1 in chronic pain |
| title_fullStr | Role of EPAC1 in chronic pain |
| title_full_unstemmed | Role of EPAC1 in chronic pain |
| title_short | Role of EPAC1 in chronic pain |
| title_sort | role of epac1 in chronic pain |
| topic | EPAC1 Chronic pain Neuropathic pain Protein kinase Ion channel |
| url | http://www.sciencedirect.com/science/article/pii/S2405580824000098 |
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