Combined heterozygosity of FLT3ITD, TET2, and DNMT3A results in aggressive leukemia
Heterozygous mutations in FLT3ITD, TET2, and DNMT3A are associated with hematologic malignancies in humans. In patients, cooccurrence of mutations in FLT3ITD combined with TET2 (TF) or FLT3ITD combined with DNMT3A (DF) are frequent. However, in some rare complex acute myeloid leukemia (AML), all 3 m...
| Main Authors: | , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
American Society for Clinical investigation
2022-09-01
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| 丛编: | JCI Insight |
| 主题: | |
| 在线阅读: | https://doi.org/10.1172/jci.insight.162016 |