FMRI response to acute psychological stress differentiates patients with psychogenic non-epileptic seizures from healthy controls – A biochemical and neuroimaging biomarker study
We investigated psychological stress response in the brain regions involved in emotion-motor-executive control in psychogenic non-epileptic seizures (PNES). 12 PNES patients and 12 healthy controls (HCs) underwent stress task and resting state functional MRI (fMRI), mood and quality of life (QOL) as...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158219303171 |
| _version_ | 1818483127422550016 |
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| author | Jane B. Allendorfer Rodolphe Nenert Kathleen A. Hernando Jennifer L. DeWolfe Sandipan Pati Ashley E. Thomas Neil Billeaud Roy C. Martin Jerzy P. Szaflarski |
| author_facet | Jane B. Allendorfer Rodolphe Nenert Kathleen A. Hernando Jennifer L. DeWolfe Sandipan Pati Ashley E. Thomas Neil Billeaud Roy C. Martin Jerzy P. Szaflarski |
| author_sort | Jane B. Allendorfer |
| collection | DOAJ |
| description | We investigated psychological stress response in the brain regions involved in emotion-motor-executive control in psychogenic non-epileptic seizures (PNES). 12 PNES patients and 12 healthy controls (HCs) underwent stress task and resting state functional MRI (fMRI), mood and quality of life (QOL) assessments, and measurements of salivary cortisol, alpha-amylase, and heart rate. Group differences were assessed, and we correlated beta values from a priori selected brain regions showing stress task fMRI group differences with other stress response measures. We also used the regions showing stress task fMRI group differences as seeds for resting state functional connectivity (rs-FC) analysis. Mood and QOL were worse in PNES versus HCs. Physiological and assessment measures were similar except ‘Planful Problem Solving’ coping that was greater for HCs (p = .043). Perceived stress associated negatively with heart rate change (rs = −0.74, p = .0063). There was stress fMRI hyporeactivity in left/right amygdala and left hippocampus in PNES versus HCs (corrected p < .05). PNES exhibited a positive association between alpha-amylase change and right amygdala activation (rs = 0.71, p = .010). PNES versus HCs exhibited greater right amygdala rs-FC to left precentral and inferior/middle frontal gyri (corrected p < .05). Our findings of fMRI hyporeactivity to psychological stress, along with greater emotion-motor-executive control network rs-FC in PNES when compared to HCs suggest a dysregulation in stress response circuitry in PNES. Keywords: Psychogenic non-epileptic seizures (PNES), fMRI, Cortisol, Alpha-amylase, Psychological stress, Emotion |
| first_indexed | 2024-12-10T11:56:14Z |
| format | Article |
| id | doaj.art-1b54e5d416b844b698b52a5c2d8ecf77 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-10T11:56:14Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-1b54e5d416b844b698b52a5c2d8ecf772022-12-22T01:49:47ZengElsevierNeuroImage: Clinical2213-15822019-01-0124FMRI response to acute psychological stress differentiates patients with psychogenic non-epileptic seizures from healthy controls – A biochemical and neuroimaging biomarker studyJane B. Allendorfer0Rodolphe Nenert1Kathleen A. Hernando2Jennifer L. DeWolfe3Sandipan Pati4Ashley E. Thomas5Neil Billeaud6Roy C. Martin7Jerzy P. Szaflarski8Department of Neurology, The UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USA; Corresponding author at: Department of Neurology, University of Alabama at Birmingham (UAB) Epilepsy Center, 312 Civitan International Research Center, 1719 6th Avenue South, Birmingham, AL 35294, USA.Department of Neurology, The UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Neurology, The UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Neurology, The UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Neurology, The UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Neurology, The UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Neurology, The UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Neurology, The UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USADepartment of Neurology, The UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USAWe investigated psychological stress response in the brain regions involved in emotion-motor-executive control in psychogenic non-epileptic seizures (PNES). 12 PNES patients and 12 healthy controls (HCs) underwent stress task and resting state functional MRI (fMRI), mood and quality of life (QOL) assessments, and measurements of salivary cortisol, alpha-amylase, and heart rate. Group differences were assessed, and we correlated beta values from a priori selected brain regions showing stress task fMRI group differences with other stress response measures. We also used the regions showing stress task fMRI group differences as seeds for resting state functional connectivity (rs-FC) analysis. Mood and QOL were worse in PNES versus HCs. Physiological and assessment measures were similar except ‘Planful Problem Solving’ coping that was greater for HCs (p = .043). Perceived stress associated negatively with heart rate change (rs = −0.74, p = .0063). There was stress fMRI hyporeactivity in left/right amygdala and left hippocampus in PNES versus HCs (corrected p < .05). PNES exhibited a positive association between alpha-amylase change and right amygdala activation (rs = 0.71, p = .010). PNES versus HCs exhibited greater right amygdala rs-FC to left precentral and inferior/middle frontal gyri (corrected p < .05). Our findings of fMRI hyporeactivity to psychological stress, along with greater emotion-motor-executive control network rs-FC in PNES when compared to HCs suggest a dysregulation in stress response circuitry in PNES. Keywords: Psychogenic non-epileptic seizures (PNES), fMRI, Cortisol, Alpha-amylase, Psychological stress, Emotionhttp://www.sciencedirect.com/science/article/pii/S2213158219303171 |
| spellingShingle | Jane B. Allendorfer Rodolphe Nenert Kathleen A. Hernando Jennifer L. DeWolfe Sandipan Pati Ashley E. Thomas Neil Billeaud Roy C. Martin Jerzy P. Szaflarski FMRI response to acute psychological stress differentiates patients with psychogenic non-epileptic seizures from healthy controls – A biochemical and neuroimaging biomarker study NeuroImage: Clinical |
| title | FMRI response to acute psychological stress differentiates patients with psychogenic non-epileptic seizures from healthy controls – A biochemical and neuroimaging biomarker study |
| title_full | FMRI response to acute psychological stress differentiates patients with psychogenic non-epileptic seizures from healthy controls – A biochemical and neuroimaging biomarker study |
| title_fullStr | FMRI response to acute psychological stress differentiates patients with psychogenic non-epileptic seizures from healthy controls – A biochemical and neuroimaging biomarker study |
| title_full_unstemmed | FMRI response to acute psychological stress differentiates patients with psychogenic non-epileptic seizures from healthy controls – A biochemical and neuroimaging biomarker study |
| title_short | FMRI response to acute psychological stress differentiates patients with psychogenic non-epileptic seizures from healthy controls – A biochemical and neuroimaging biomarker study |
| title_sort | fmri response to acute psychological stress differentiates patients with psychogenic non epileptic seizures from healthy controls a biochemical and neuroimaging biomarker study |
| url | http://www.sciencedirect.com/science/article/pii/S2213158219303171 |
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