The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms
Abstract Understanding and facilitating healthy aging has become a major goal in medical research and it is becoming increasingly acknowledged that there is a need for understanding the aging phenotype as a whole rather than focusing on individual factors. Here, we provide a universal explanation fo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-51669-5 |
| _version_ | 1827382247903199232 |
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| author | Pernille Yde Nielsen Majken K Jensen Namiko Mitarai Samir Bhatt |
| author_facet | Pernille Yde Nielsen Majken K Jensen Namiko Mitarai Samir Bhatt |
| author_sort | Pernille Yde Nielsen |
| collection | DOAJ |
| description | Abstract Understanding and facilitating healthy aging has become a major goal in medical research and it is becoming increasingly acknowledged that there is a need for understanding the aging phenotype as a whole rather than focusing on individual factors. Here, we provide a universal explanation for the emergence of Gompertzian mortality patterns using a systems approach to describe aging in complex organisms that consist of many inter-dependent subsystems. Our model relates to the Sufficient-Component Cause Model, widely used within the field of epidemiology, and we show that including inter-dependencies between subsystems and modeling the temporal evolution of subsystem failure results in Gompertizan mortality on the population level. Our model also provides temporal trajectories of mortality-risk for the individual. These results may give insight into understanding how biological age evolves stochastically within the individual, and how this in turn leads to a natural heterogeneity of biological age in a population. |
| first_indexed | 2024-03-08T14:16:53Z |
| format | Article |
| id | doaj.art-1b5593e858c74852a0c0078726e58afe |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T14:16:53Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1b5593e858c74852a0c0078726e58afe2024-01-14T12:20:07ZengNature PortfolioScientific Reports2045-23222024-01-0114111110.1038/s41598-024-51669-5The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organismsPernille Yde Nielsen0Majken K Jensen1Namiko Mitarai2Samir Bhatt3Department of Applied Mathematics and Computer Science, Technical University of DenmarkDepartment of Public Health, University of CopenhagenNiels Bohr Institute, University of CopenhagenDepartment of Public Health, University of CopenhagenAbstract Understanding and facilitating healthy aging has become a major goal in medical research and it is becoming increasingly acknowledged that there is a need for understanding the aging phenotype as a whole rather than focusing on individual factors. Here, we provide a universal explanation for the emergence of Gompertzian mortality patterns using a systems approach to describe aging in complex organisms that consist of many inter-dependent subsystems. Our model relates to the Sufficient-Component Cause Model, widely used within the field of epidemiology, and we show that including inter-dependencies between subsystems and modeling the temporal evolution of subsystem failure results in Gompertizan mortality on the population level. Our model also provides temporal trajectories of mortality-risk for the individual. These results may give insight into understanding how biological age evolves stochastically within the individual, and how this in turn leads to a natural heterogeneity of biological age in a population.https://doi.org/10.1038/s41598-024-51669-5 |
| spellingShingle | Pernille Yde Nielsen Majken K Jensen Namiko Mitarai Samir Bhatt The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms Scientific Reports |
| title | The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms |
| title_full | The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms |
| title_fullStr | The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms |
| title_full_unstemmed | The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms |
| title_short | The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms |
| title_sort | gompertz law emerges naturally from the inter dependencies between sub components in complex organisms |
| url | https://doi.org/10.1038/s41598-024-51669-5 |
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