Exploration of Cytochrome P450-Related Interactions between Aflatoxin B1 and Tiamulin in Broiler Chickens

Exploration of Cytochrome P450-Related Interactions between Aflatoxin B1 and Tiamulin in Broiler Chickens

Poultry may face simultaneous exposure to aflatoxin B1 (AFB1) and tiamulin (TIA), given mycotoxin contamination and antibiotic use. As both mycotoxins and antibiotics can affect cytochrome P450 enzymes (CYP450), our study aimed to explore their interaction. We developed UHPLC-MS/MS methods for the f...

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Bibliographic Details
Main Authors: Pan Sun, Orphélie Lootens, Tadele Kabeta, Diethard Reckelbus, Natalia Furman, Xingyuan Cao, Suxia Zhang, Gunther Antonissen, Siska Croubels, Marthe De Boevre, Sarah De Saeger
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Toxins
Subjects:
CYP450 enzymes
tiamulin
aflatoxin B1
broiler chicken
mycotoxin-drug interaction
pharmacokinetics
Online Access:https://www.mdpi.com/2072-6651/16/3/160

Internet

https://www.mdpi.com/2072-6651/16/3/160

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