Immunothrombosis and thromboinflammation in host defense and disease
Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macropha...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-04-01
|
| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2020.1817360 |
| _version_ | 1797684114427478016 |
|---|---|
| author | Kimberly Martinod Carsten Deppermann |
| author_facet | Kimberly Martinod Carsten Deppermann |
| author_sort | Kimberly Martinod |
| collection | DOAJ |
| description | Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein thrombosis during infection, e.g. in COVID-19 patients. |
| first_indexed | 2024-03-12T00:25:54Z |
| format | Article |
| id | doaj.art-1b5871dac95149d294e30230fee1edef |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:54Z |
| publishDate | 2021-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-1b5871dac95149d294e30230fee1edef2023-09-15T10:38:08ZengTaylor & Francis GroupPlatelets0953-71041369-16352021-04-0132331432410.1080/09537104.2020.18173601817360Immunothrombosis and thromboinflammation in host defense and diseaseKimberly Martinod0Carsten Deppermann1Center for Molecular and Vascular Biology, Department of Cardiovascular SciencesUniversity Medical Center Hamburg-EppendorfPlatelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein thrombosis during infection, e.g. in COVID-19 patients.http://dx.doi.org/10.1080/09537104.2020.1817360covid-19immunothrombosismacrophagesmyocardial infarctionnetsneutrophil extracellular trapsneutrophilsplateletssepsisstroke |
| spellingShingle | Kimberly Martinod Carsten Deppermann Immunothrombosis and thromboinflammation in host defense and disease Platelets covid-19 immunothrombosis macrophages myocardial infarction nets neutrophil extracellular traps neutrophils platelets sepsis stroke |
| title | Immunothrombosis and thromboinflammation in host defense and disease |
| title_full | Immunothrombosis and thromboinflammation in host defense and disease |
| title_fullStr | Immunothrombosis and thromboinflammation in host defense and disease |
| title_full_unstemmed | Immunothrombosis and thromboinflammation in host defense and disease |
| title_short | Immunothrombosis and thromboinflammation in host defense and disease |
| title_sort | immunothrombosis and thromboinflammation in host defense and disease |
| topic | covid-19 immunothrombosis macrophages myocardial infarction nets neutrophil extracellular traps neutrophils platelets sepsis stroke |
| url | http://dx.doi.org/10.1080/09537104.2020.1817360 |
| work_keys_str_mv | AT kimberlymartinod immunothrombosisandthromboinflammationinhostdefenseanddisease AT carstendeppermann immunothrombosisandthromboinflammationinhostdefenseanddisease |