RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer

RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer

Abstract Background RelA/p65 a crucial member of NF-κB signaling pathway plays diverse role in mediating oncogenesis. Limited knowledge prevails on the mechanistic insights of RelA gene regulation. RNA helicase p68 apart from being a vital player of RNA metabolism acts as a transcriptional coactivat...

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Bibliographic Details
Main Authors: Veenita Khare, Shaheda Tabassum, Uttara Chatterjee, Sandip Chatterjee, Mrinal K. Ghosh
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
RNA helicase p68
Wnt/β-catenin signaling
NF-κB signaling cascade
RelA gene regulation
Murine model
Online Access:http://link.springer.com/article/10.1186/s13046-019-1304-y

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