Ablation of TRPV1 Abolishes Salicylate-Induced Sympathetic Activity Suppression and Exacerbates Salicylate-Induced Renal Dysfunction in Diet-Induced Obesity

Ablation of TRPV1 Abolishes Salicylate-Induced Sympathetic Activity Suppression and Exacerbates Salicylate-Induced Renal Dysfunction in Diet-Induced Obesity

Sodium salicylate (SA), a cyclooxygenase inhibitor, has been shown to increase insulin sensitivity and to suppress inflammation in obese patients and animal models. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel expressed in afferent nerve fibers. Cyclooxygenase-de...

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Bibliographic Details
Main Authors: Beihua Zhong, Shuangtao Ma, Donna H. Wang
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
TRPV1
obesity
sodium salicylate
afferent renal nerve activity
renal dysfunction
blood pressure
Online Access:https://www.mdpi.com/2073-4409/10/5/1234

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