Antivirals against the Chikungunya Virus
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection leads to a febrile disease known as chikungunya fever (CHIKF), which is characterised by severe joint pain and myalgia. As m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/7/1307 |
| _version_ | 1797525896122335232 |
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| author | Verena Battisti Ernst Urban Thierry Langer |
| author_facet | Verena Battisti Ernst Urban Thierry Langer |
| author_sort | Verena Battisti |
| collection | DOAJ |
| description | Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection leads to a febrile disease known as chikungunya fever (CHIKF), which is characterised by severe joint pain and myalgia. As many patients develop a painful chronic stage and neither antiviral drugs nor vaccines are available, the development of a potent CHIKV inhibiting drug is crucial for CHIKF treatment. A comprehensive summary of current antiviral research and development of small-molecule inhibitor against CHIKV is presented in this review. We highlight different approaches used for the identification of such compounds and further discuss the identification and application of promising viral and host targets. |
| first_indexed | 2024-03-10T09:20:30Z |
| format | Article |
| id | doaj.art-1b60357e2c104414bb02bb758e363f75 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T09:20:30Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-1b60357e2c104414bb02bb758e363f752023-11-22T05:13:56ZengMDPI AGViruses1999-49152021-07-01137130710.3390/v13071307Antivirals against the Chikungunya VirusVerena Battisti0Ernst Urban1Thierry Langer2Department of Pharmaceutical Sciences, Pharmaceutical Chemistry Division, University of Vienna, A-1090 Vienna, AustriaDepartment of Pharmaceutical Sciences, Pharmaceutical Chemistry Division, University of Vienna, A-1090 Vienna, AustriaDepartment of Pharmaceutical Sciences, Pharmaceutical Chemistry Division, University of Vienna, A-1090 Vienna, AustriaChikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection leads to a febrile disease known as chikungunya fever (CHIKF), which is characterised by severe joint pain and myalgia. As many patients develop a painful chronic stage and neither antiviral drugs nor vaccines are available, the development of a potent CHIKV inhibiting drug is crucial for CHIKF treatment. A comprehensive summary of current antiviral research and development of small-molecule inhibitor against CHIKV is presented in this review. We highlight different approaches used for the identification of such compounds and further discuss the identification and application of promising viral and host targets.https://www.mdpi.com/1999-4915/13/7/1307Chikungunya virusalphavirusantiviral therapydirect-acting antiviralshost-directed antiviralsin silico screening |
| spellingShingle | Verena Battisti Ernst Urban Thierry Langer Antivirals against the Chikungunya Virus Viruses Chikungunya virus alphavirus antiviral therapy direct-acting antivirals host-directed antivirals in silico screening |
| title | Antivirals against the Chikungunya Virus |
| title_full | Antivirals against the Chikungunya Virus |
| title_fullStr | Antivirals against the Chikungunya Virus |
| title_full_unstemmed | Antivirals against the Chikungunya Virus |
| title_short | Antivirals against the Chikungunya Virus |
| title_sort | antivirals against the chikungunya virus |
| topic | Chikungunya virus alphavirus antiviral therapy direct-acting antivirals host-directed antivirals in silico screening |
| url | https://www.mdpi.com/1999-4915/13/7/1307 |
| work_keys_str_mv | AT verenabattisti antiviralsagainstthechikungunyavirus AT ernsturban antiviralsagainstthechikungunyavirus AT thierrylanger antiviralsagainstthechikungunyavirus |