The İmportance of tumor markers in patients undergoing resection for lung metastasis of colorectal carcinoma
Abstract Objectives In patients with suitable conditions, complete resection is a potential curative treatment for lung metastases of colorectal cancers (CRC). Various prognostic factors affecting survival have been reported in these patients. In our study, the prognostic significance of CEA and CA1...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | The Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/crj.13611 |
| _version_ | 1797818827646435328 |
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| author | Gizem Kececi Ozgur Ahmet Kayahan Tekneci Edward Hassan Bakali Tevfik Ilker Akcam Ayse Gul Ergonul Ali Ozdil Kutsal Turhan Alpaslan Cakan Ufuk Cagırıcı |
| author_facet | Gizem Kececi Ozgur Ahmet Kayahan Tekneci Edward Hassan Bakali Tevfik Ilker Akcam Ayse Gul Ergonul Ali Ozdil Kutsal Turhan Alpaslan Cakan Ufuk Cagırıcı |
| author_sort | Gizem Kececi Ozgur |
| collection | DOAJ |
| description | Abstract Objectives In patients with suitable conditions, complete resection is a potential curative treatment for lung metastases of colorectal cancers (CRC). Various prognostic factors affecting survival have been reported in these patients. In our study, the prognostic significance of CEA and CA19‐9 tumor markers in patients who underwent lung resection for CRC metastasis was researched. Methods Fifty‐three patients who underwent lung resection for CRC metastasis between January 2015 and July 2021 were included in the study. The relationship between preoperative and postoperative CEA and CA19‐9 values, survival times, tumor size, and preoperative CEA and CA19‐9 levels were investigated. Results Patients with high preoperative and postoperative CEA had shorter survival (OS) compared with patients with lower values (p ≤ 0.001 and p = 0.009, respectively). Disease‐free survival (DFS) was also shorter in patients with higher preoperative CEA values (p = 0.008). For patients with higher preoperative and postoperative CA 19–9 values, OS and DFS were shorter (p = 0.013 and p ≤ 0.001) and (p = 0.042 and p ≤ 0.001), respectively. There was a weak positive correlation between preoperative CEA value and tumor size (p = 0.008, Pearson correlation coefficient = 0.360). However, a strong positive correlation between preoperative CA19‐9 value and tumor size was discovered (p ≤ 0.001, Pearson correlation coefficient = 0.603). Conclusion In our study, it was shown that preoperative‐postoperative CEA and CA19‐9 levels in patients with metastatic colon carcinoma are associated with overall survival. |
| first_indexed | 2024-03-13T09:14:51Z |
| format | Article |
| id | doaj.art-1b61c14424d2490e99511da3cb1d1b9f |
| institution | Directory Open Access Journal |
| issn | 1752-6981 1752-699X |
| language | English |
| last_indexed | 2024-03-13T09:14:51Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj.art-1b61c14424d2490e99511da3cb1d1b9f2023-05-26T10:50:31ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2023-05-0117542943810.1111/crj.13611The İmportance of tumor markers in patients undergoing resection for lung metastasis of colorectal carcinomaGizem Kececi Ozgur0Ahmet Kayahan Tekneci1Edward Hassan Bakali2Tevfik Ilker Akcam3Ayse Gul Ergonul4Ali Ozdil5Kutsal Turhan6Alpaslan Cakan7Ufuk Cagırıcı8Department of Thoracic Surgery Ege University School of Medicine Izmir TurkeyDepartment of Thoracic Surgery Ege University School of Medicine Izmir TurkeyDepartment of Thoracic Surgery Ege University School of Medicine Izmir TurkeyDepartment of Thoracic Surgery Ege University School of Medicine Izmir TurkeyDepartment of Thoracic Surgery Ege University School of Medicine Izmir TurkeyDepartment of Thoracic Surgery Ege University School of Medicine Izmir TurkeyDepartment of Thoracic Surgery Ege University School of Medicine Izmir TurkeyDepartment of Thoracic Surgery Ege University School of Medicine Izmir TurkeyDepartment of Thoracic Surgery Ege University School of Medicine Izmir TurkeyAbstract Objectives In patients with suitable conditions, complete resection is a potential curative treatment for lung metastases of colorectal cancers (CRC). Various prognostic factors affecting survival have been reported in these patients. In our study, the prognostic significance of CEA and CA19‐9 tumor markers in patients who underwent lung resection for CRC metastasis was researched. Methods Fifty‐three patients who underwent lung resection for CRC metastasis between January 2015 and July 2021 were included in the study. The relationship between preoperative and postoperative CEA and CA19‐9 values, survival times, tumor size, and preoperative CEA and CA19‐9 levels were investigated. Results Patients with high preoperative and postoperative CEA had shorter survival (OS) compared with patients with lower values (p ≤ 0.001 and p = 0.009, respectively). Disease‐free survival (DFS) was also shorter in patients with higher preoperative CEA values (p = 0.008). For patients with higher preoperative and postoperative CA 19–9 values, OS and DFS were shorter (p = 0.013 and p ≤ 0.001) and (p = 0.042 and p ≤ 0.001), respectively. There was a weak positive correlation between preoperative CEA value and tumor size (p = 0.008, Pearson correlation coefficient = 0.360). However, a strong positive correlation between preoperative CA19‐9 value and tumor size was discovered (p ≤ 0.001, Pearson correlation coefficient = 0.603). Conclusion In our study, it was shown that preoperative‐postoperative CEA and CA19‐9 levels in patients with metastatic colon carcinoma are associated with overall survival.https://doi.org/10.1111/crj.13611CA 19‐9 valuecolorectal carcinomalung metastasespulmonary metastasectomy |
| spellingShingle | Gizem Kececi Ozgur Ahmet Kayahan Tekneci Edward Hassan Bakali Tevfik Ilker Akcam Ayse Gul Ergonul Ali Ozdil Kutsal Turhan Alpaslan Cakan Ufuk Cagırıcı The İmportance of tumor markers in patients undergoing resection for lung metastasis of colorectal carcinoma The Clinical Respiratory Journal CA 19‐9 value colorectal carcinoma lung metastases pulmonary metastasectomy |
| title | The İmportance of tumor markers in patients undergoing resection for lung metastasis of colorectal carcinoma |
| title_full | The İmportance of tumor markers in patients undergoing resection for lung metastasis of colorectal carcinoma |
| title_fullStr | The İmportance of tumor markers in patients undergoing resection for lung metastasis of colorectal carcinoma |
| title_full_unstemmed | The İmportance of tumor markers in patients undergoing resection for lung metastasis of colorectal carcinoma |
| title_short | The İmportance of tumor markers in patients undergoing resection for lung metastasis of colorectal carcinoma |
| title_sort | importance of tumor markers in patients undergoing resection for lung metastasis of colorectal carcinoma |
| topic | CA 19‐9 value colorectal carcinoma lung metastases pulmonary metastasectomy |
| url | https://doi.org/10.1111/crj.13611 |
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