Exploring the inhibitory potential of in silico-designed small peptides on Helicobacter pylori Hp0231 (DsbK), a periplasmic oxidoreductase involved in disulfide bond formation

Exploring the inhibitory potential of in silico-designed small peptides on Helicobacter pylori Hp0231 (DsbK), a periplasmic oxidoreductase involved in disulfide bond formation

Introduction:Helicobacter pylori is a bacterium that colonizes the gastric epithelium, which affects millions of people worldwide. H. pylori infection can lead to various gastrointestinal diseases, including gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Conventional antibiot...

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Bibliographic Details
Main Authors: Paula Roszczenko-Jasińska, Artur Giełdoń, Dominika Mazur, Marta Spodzieja, Maciej Plichta, Cezary Czaplewski, Wojciech Bal, Elzbieta K. Jagusztyn-Krynicka, Dariusz Bartosik
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
Helicobacter pylori
disulfide bond proteins
Hp0231 oxidoreductase
peptide-based inhibitors
Dsb targeting inhibitors
structure-based drug design
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1335704/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1335704/full

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