Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome
Polycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA have been identified in PCOS patients and likely play an important role in P...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/8/3923 |
| _version_ | 1797538106040123392 |
|---|---|
| author | Siarhei A. Dabravolski Nikita G. Nikiforov Ali H. Eid Ludmila V. Nedosugova Antonina V. Starodubova Tatyana V. Popkova Evgeny E. Bezsonov Alexander N. Orekhov |
| author_facet | Siarhei A. Dabravolski Nikita G. Nikiforov Ali H. Eid Ludmila V. Nedosugova Antonina V. Starodubova Tatyana V. Popkova Evgeny E. Bezsonov Alexander N. Orekhov |
| author_sort | Siarhei A. Dabravolski |
| collection | DOAJ |
| description | Polycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA have been identified in PCOS patients and likely play an important role in PCOS aetiology and pathogenesis; however, their causative role in PCOS development requires further investigation. As a low-grade chronic inflammation disease, PCOS patients have permanently elevated levels of inflammatory markers (TNF-α, CRP, IL-6, IL-8, IL-18). In this review, we summarise recent data regarding the role of mtDNA mutations and mitochondrial malfunctions in PCOS pathogenesis. Furthermore, we discuss recent papers dedicated to the identification of novel biomarkers for early PCOS diagnosis. Finally, traditional and new mitochondria-targeted treatments are discussed. This review intends to emphasise the key role of oxidative stress and chronic inflammation in PCOS pathogenesis; however, the exact molecular mechanism is mostly unknown and requires further investigation. |
| first_indexed | 2024-03-10T12:25:47Z |
| format | Article |
| id | doaj.art-1b656ecf3e8441e08d947178ae8d7b23 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:25:47Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1b656ecf3e8441e08d947178ae8d7b232023-11-21T15:00:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228392310.3390/ijms22083923Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary SyndromeSiarhei A. Dabravolski0Nikita G. Nikiforov1Ali H. Eid2Ludmila V. Nedosugova3Antonina V. Starodubova4Tatyana V. Popkova5Evgeny E. Bezsonov6Alexander N. Orekhov7Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine [UO VGAVM], 7/11 Dovatora str., 210026 Vitebsk, BelarusCenter of Collective Usage, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilova Street, 119334 Moscow, RussiaDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha 2713, QatarFederal State Autonomous Educational Institution of Higher Education, I. M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubenskaya Street, 119991 Moscow, RussiaFederal Research Centre for Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Passage, 109240 Moscow, RussiaV.A. Nasonova Institute of Rheumatology, 34A Kashirskoye Shosse, 115522 Moscow, RussiaLaboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, RussiaLaboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, RussiaPolycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA have been identified in PCOS patients and likely play an important role in PCOS aetiology and pathogenesis; however, their causative role in PCOS development requires further investigation. As a low-grade chronic inflammation disease, PCOS patients have permanently elevated levels of inflammatory markers (TNF-α, CRP, IL-6, IL-8, IL-18). In this review, we summarise recent data regarding the role of mtDNA mutations and mitochondrial malfunctions in PCOS pathogenesis. Furthermore, we discuss recent papers dedicated to the identification of novel biomarkers for early PCOS diagnosis. Finally, traditional and new mitochondria-targeted treatments are discussed. This review intends to emphasise the key role of oxidative stress and chronic inflammation in PCOS pathogenesis; however, the exact molecular mechanism is mostly unknown and requires further investigation.https://www.mdpi.com/1422-0067/22/8/3923polycystic ovarian syndromeinsulin resistancechronic inflammationoxidative stressmitochondrial mutations |
| spellingShingle | Siarhei A. Dabravolski Nikita G. Nikiforov Ali H. Eid Ludmila V. Nedosugova Antonina V. Starodubova Tatyana V. Popkova Evgeny E. Bezsonov Alexander N. Orekhov Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome International Journal of Molecular Sciences polycystic ovarian syndrome insulin resistance chronic inflammation oxidative stress mitochondrial mutations |
| title | Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome |
| title_full | Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome |
| title_fullStr | Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome |
| title_full_unstemmed | Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome |
| title_short | Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome |
| title_sort | mitochondrial dysfunction and chronic inflammation in polycystic ovary syndrome |
| topic | polycystic ovarian syndrome insulin resistance chronic inflammation oxidative stress mitochondrial mutations |
| url | https://www.mdpi.com/1422-0067/22/8/3923 |
| work_keys_str_mv | AT siarheiadabravolski mitochondrialdysfunctionandchronicinflammationinpolycysticovarysyndrome AT nikitagnikiforov mitochondrialdysfunctionandchronicinflammationinpolycysticovarysyndrome AT aliheid mitochondrialdysfunctionandchronicinflammationinpolycysticovarysyndrome AT ludmilavnedosugova mitochondrialdysfunctionandchronicinflammationinpolycysticovarysyndrome AT antoninavstarodubova mitochondrialdysfunctionandchronicinflammationinpolycysticovarysyndrome AT tatyanavpopkova mitochondrialdysfunctionandchronicinflammationinpolycysticovarysyndrome AT evgenyebezsonov mitochondrialdysfunctionandchronicinflammationinpolycysticovarysyndrome AT alexandernorekhov mitochondrialdysfunctionandchronicinflammationinpolycysticovarysyndrome |