Extensive Angular Sampling Enables the Sensitive Localization of Macromolecules in Electron Tomograms

Extensive Angular Sampling Enables the Sensitive Localization of Macromolecules in Electron Tomograms

Cryo-electron tomography provides 3D images of macromolecules in their cellular context. To detect macromolecules in tomograms, template matching (TM) is often used, which uses 3D models that are often reliable for substantial parts of the macromolecules. However, the extent of rotational searches i...

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Bibliographic Details
Main Authors: Marten L. Chaillet, Gijs van der Schot, Ilja Gubins, Sander Roet, Remco C. Veltkamp, Friedrich Förster
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
electron cryo-tomography
particle localization and identification
template matching
GPU acceleration
volume registration
Online Access:https://www.mdpi.com/1422-0067/24/17/13375

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