Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile Mice
Ischemic damage to the brain and loss of neurons contribute to functional disabilities in many stroke survivors. Recovery of neuroplasticity is critical to restoration of function and improved quality of life. Stroke and neurological deficits occur in both adults and children, and yet it is well doc...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/13/9/1337 |
| _version_ | 1797581008406577152 |
|---|---|
| author | Ricaurte A. Marquez-Ortiz Vesna Tesic Daniel R. Hernandez Bilkis Akhter Nibedita Aich Porter M. Boudreaux Garrett A. Clemons Celeste Yin-Chieh Wu Hung Wen Lin Krista M. Rodgers |
| author_facet | Ricaurte A. Marquez-Ortiz Vesna Tesic Daniel R. Hernandez Bilkis Akhter Nibedita Aich Porter M. Boudreaux Garrett A. Clemons Celeste Yin-Chieh Wu Hung Wen Lin Krista M. Rodgers |
| author_sort | Ricaurte A. Marquez-Ortiz |
| collection | DOAJ |
| description | Ischemic damage to the brain and loss of neurons contribute to functional disabilities in many stroke survivors. Recovery of neuroplasticity is critical to restoration of function and improved quality of life. Stroke and neurological deficits occur in both adults and children, and yet it is well documented that the developing brain has remarkable plasticity which promotes increased post-ischemic functional recovery compared with adults. However, the mechanisms underlying post-stroke recovery in the young brain have not been fully explored. We observed opposing responses to experimental cerebral ischemia in juvenile and adult mice, with substantial neural regeneration and enhanced neuroplasticity detected in the juvenile brain that was not found in adults. We demonstrate strikingly different stroke-induced neuroimmune responses that are deleterious in adults and protective in juveniles, supporting neural regeneration and plasticity. Understanding age-related differences in neuronal repair and regeneration, restoration of neural network function, and neuroimmune signaling in the stroke-injured brain may offer new insights for the development of novel therapeutic strategies for stroke rehabilitation. |
| first_indexed | 2024-03-10T22:57:58Z |
| format | Article |
| id | doaj.art-1b675c837332439ca1d33eb998b79808 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T22:57:58Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-1b675c837332439ca1d33eb998b798082023-11-19T09:49:30ZengMDPI AGBrain Sciences2076-34252023-09-01139133710.3390/brainsci13091337Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile MiceRicaurte A. Marquez-Ortiz0Vesna Tesic1Daniel R. Hernandez2Bilkis Akhter3Nibedita Aich4Porter M. Boudreaux5Garrett A. Clemons6Celeste Yin-Chieh Wu7Hung Wen Lin8Krista M. Rodgers9Department of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA 70803, USADepartment of Neurology, Louisiana State University, Health Sciences Center, Shreveport, LA 70803, USADepartment of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA 70803, USADepartment of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA 70803, USADepartment of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA 70803, USADepartment of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA 70803, USADepartment of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA 70803, USADepartment of Neurology, Louisiana State University, Health Sciences Center, Shreveport, LA 70803, USADepartment of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA 70803, USADepartment of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA 70803, USAIschemic damage to the brain and loss of neurons contribute to functional disabilities in many stroke survivors. Recovery of neuroplasticity is critical to restoration of function and improved quality of life. Stroke and neurological deficits occur in both adults and children, and yet it is well documented that the developing brain has remarkable plasticity which promotes increased post-ischemic functional recovery compared with adults. However, the mechanisms underlying post-stroke recovery in the young brain have not been fully explored. We observed opposing responses to experimental cerebral ischemia in juvenile and adult mice, with substantial neural regeneration and enhanced neuroplasticity detected in the juvenile brain that was not found in adults. We demonstrate strikingly different stroke-induced neuroimmune responses that are deleterious in adults and protective in juveniles, supporting neural regeneration and plasticity. Understanding age-related differences in neuronal repair and regeneration, restoration of neural network function, and neuroimmune signaling in the stroke-injured brain may offer new insights for the development of novel therapeutic strategies for stroke rehabilitation.https://www.mdpi.com/2076-3425/13/9/1337cerebral ischemianeural regenerationneurogenesissynaptic plasticityfunctional recoveryneuroimmune signaling |
| spellingShingle | Ricaurte A. Marquez-Ortiz Vesna Tesic Daniel R. Hernandez Bilkis Akhter Nibedita Aich Porter M. Boudreaux Garrett A. Clemons Celeste Yin-Chieh Wu Hung Wen Lin Krista M. Rodgers Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile Mice Brain Sciences cerebral ischemia neural regeneration neurogenesis synaptic plasticity functional recovery neuroimmune signaling |
| title | Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile Mice |
| title_full | Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile Mice |
| title_fullStr | Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile Mice |
| title_full_unstemmed | Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile Mice |
| title_short | Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile Mice |
| title_sort | neuroimmune support of neuronal regeneration and neuroplasticity following cerebral ischemia in juvenile mice |
| topic | cerebral ischemia neural regeneration neurogenesis synaptic plasticity functional recovery neuroimmune signaling |
| url | https://www.mdpi.com/2076-3425/13/9/1337 |
| work_keys_str_mv | AT ricaurteamarquezortiz neuroimmunesupportofneuronalregenerationandneuroplasticityfollowingcerebralischemiainjuvenilemice AT vesnatesic neuroimmunesupportofneuronalregenerationandneuroplasticityfollowingcerebralischemiainjuvenilemice AT danielrhernandez neuroimmunesupportofneuronalregenerationandneuroplasticityfollowingcerebralischemiainjuvenilemice AT bilkisakhter neuroimmunesupportofneuronalregenerationandneuroplasticityfollowingcerebralischemiainjuvenilemice AT nibeditaaich neuroimmunesupportofneuronalregenerationandneuroplasticityfollowingcerebralischemiainjuvenilemice AT portermboudreaux neuroimmunesupportofneuronalregenerationandneuroplasticityfollowingcerebralischemiainjuvenilemice AT garrettaclemons neuroimmunesupportofneuronalregenerationandneuroplasticityfollowingcerebralischemiainjuvenilemice AT celesteyinchiehwu neuroimmunesupportofneuronalregenerationandneuroplasticityfollowingcerebralischemiainjuvenilemice AT hungwenlin neuroimmunesupportofneuronalregenerationandneuroplasticityfollowingcerebralischemiainjuvenilemice AT kristamrodgers neuroimmunesupportofneuronalregenerationandneuroplasticityfollowingcerebralischemiainjuvenilemice |