Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>
Methicillin resistant <i>Staphylococcus aureus</i> strains pose a serious treatment problem because of their multi-drug resistance (MDR). In staphylococcal strains, resistance to macrolides, lincosamides, and streptogramin B (MLS<sub>B</sub>) correlates with resistance to met...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/11/1406 |
| _version_ | 1827677498813448192 |
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| author | Maria Miklasińska-Majdanik |
| author_facet | Maria Miklasińska-Majdanik |
| author_sort | Maria Miklasińska-Majdanik |
| collection | DOAJ |
| description | Methicillin resistant <i>Staphylococcus aureus</i> strains pose a serious treatment problem because of their multi-drug resistance (MDR). In staphylococcal strains, resistance to macrolides, lincosamides, and streptogramin B (MLS<sub>B</sub>) correlates with resistance to methicillin. The rapid transmission of <i>erm</i> genes responsible for MLS<sub>B</sub> resistance has strongly limited the clinical application of traditional macrolides such as erythromycin. On the other hand, in the age of increasing insensitivity to antibiotics the idea of implementing a therapy based on older generation drugs brings hope that the spread of antibiotic resistance will be limited. A thorough understanding of the resistance mechanisms contributes to design of antibiotics that avoid bacterial insensitivity. This review highlights the mechanisms of action of macrolides and mechanism of resistance to these antibiotics among <i>Staphylococcus aureus</i>. |
| first_indexed | 2024-03-10T05:44:50Z |
| format | Article |
| id | doaj.art-1b68abce93b1403b956b52b6138f474e |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T05:44:50Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-1b68abce93b1403b956b52b6138f474e2023-11-22T22:11:11ZengMDPI AGAntibiotics2079-63822021-11-011011140610.3390/antibiotics10111406Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>Maria Miklasińska-Majdanik0Department of Microbiology and Virology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, PolandMethicillin resistant <i>Staphylococcus aureus</i> strains pose a serious treatment problem because of their multi-drug resistance (MDR). In staphylococcal strains, resistance to macrolides, lincosamides, and streptogramin B (MLS<sub>B</sub>) correlates with resistance to methicillin. The rapid transmission of <i>erm</i> genes responsible for MLS<sub>B</sub> resistance has strongly limited the clinical application of traditional macrolides such as erythromycin. On the other hand, in the age of increasing insensitivity to antibiotics the idea of implementing a therapy based on older generation drugs brings hope that the spread of antibiotic resistance will be limited. A thorough understanding of the resistance mechanisms contributes to design of antibiotics that avoid bacterial insensitivity. This review highlights the mechanisms of action of macrolides and mechanism of resistance to these antibiotics among <i>Staphylococcus aureus</i>.https://www.mdpi.com/2079-6382/10/11/1406macrolidesresistance<i>Staphylococcus aureus</i> |
| spellingShingle | Maria Miklasińska-Majdanik Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i> Antibiotics macrolides resistance <i>Staphylococcus aureus</i> |
| title | Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i> |
| title_full | Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i> |
| title_fullStr | Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i> |
| title_full_unstemmed | Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i> |
| title_short | Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i> |
| title_sort | mechanisms of resistance to macrolide antibiotics among i staphylococcus aureus i |
| topic | macrolides resistance <i>Staphylococcus aureus</i> |
| url | https://www.mdpi.com/2079-6382/10/11/1406 |
| work_keys_str_mv | AT mariamiklasinskamajdanik mechanismsofresistancetomacrolideantibioticsamongistaphylococcusaureusi |