Brain endothelial cells exposure to malaria parasites links type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption, and cellular metabolism

Brain endothelial cells exposure to malaria parasites links type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption, and cellular metabolism

IntroductionCerebral malaria (CM) lethality is attributable to induction of brain edema induction but the cellular mechanisms involving brain microvascular endothelium in CM pathogenesis are unexplored.ResultsActivation of the STING-INFb-CXCL10 axis in brain endothelial cells (BECs) is a prominent c...

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Bibliographic Details
Main Authors:	Abdul Muktadir Shafi, Ákos Végvári, Shanshan Wu Howland, Roman A. Zubarev, Laurent Rénia, Carlos Penha-Gonçalves
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Series:	Frontiers in Immunology
Subjects:	cerebral malaria (CM) type - 1 interferons antigen presentation endothelial cells glucose metabolic alterations proteome
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1149107/full

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