In silico Evaluation of mirror repeats within ced-9 Gene of Caenorhabditis elegans
Background: Repetitive elements constitute a significant proportion of metazoan genomes. These elements form different types of unusual structures, such as left-handed Z-DNA, triple-stranded H-DNA, G-quadruplex, and cruciform, and are related to various diseases. Methods: A simple and swift approach...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Biomedical and Biotechnology Research Journal |
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| Online Access: | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2023;volume=7;issue=2;spage=253;epage=259;aulast=Dhankhar |
| _version_ | 1797649481694445568 |
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| author | Mamta Dhankhar Deepti Yadav Vikash Bhardwaj |
| author_facet | Mamta Dhankhar Deepti Yadav Vikash Bhardwaj |
| author_sort | Mamta Dhankhar |
| collection | DOAJ |
| description | Background: Repetitive elements constitute a significant proportion of metazoan genomes. These elements form different types of unusual structures, such as left-handed Z-DNA, triple-stranded H-DNA, G-quadruplex, and cruciform, and are related to various diseases. Methods: A simple and swift approach was used for the identification of mirror repeats within ced-9 gene of Caenorhabditis elegans. Another non-B-DNA tool was also utilized for the identification of mirror repeats. Results: We identified 53 mirror repeats within ced-9 gene of C. elegans, and these identified mirror repeats were explored among the genome of other organisms such as Caenorhabditis vulgaris, Xenopus tropicalis, and Drosophila melanogaster. Conclusions: At the first time, we have characterized mirror repeats within ced-9 gene of C. elegans. We identified some homopurine- and homopyrimidine-rich sequences that have the potential to form unusual DNA structures. |
| first_indexed | 2024-03-11T15:46:47Z |
| format | Article |
| id | doaj.art-1b6a2ee267e14215be5dacc3677e5059 |
| institution | Directory Open Access Journal |
| issn | 2588-9834 2588-9842 |
| language | English |
| last_indexed | 2024-03-11T15:46:47Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Biomedical and Biotechnology Research Journal |
| spelling | doaj.art-1b6a2ee267e14215be5dacc3677e50592023-10-26T06:05:23ZengWolters Kluwer Medknow PublicationsBiomedical and Biotechnology Research Journal2588-98342588-98422023-01-017225325910.4103/bbrj.bbrj_58_23In silico Evaluation of mirror repeats within ced-9 Gene of Caenorhabditis elegansMamta DhankharDeepti YadavVikash BhardwajBackground: Repetitive elements constitute a significant proportion of metazoan genomes. These elements form different types of unusual structures, such as left-handed Z-DNA, triple-stranded H-DNA, G-quadruplex, and cruciform, and are related to various diseases. Methods: A simple and swift approach was used for the identification of mirror repeats within ced-9 gene of Caenorhabditis elegans. Another non-B-DNA tool was also utilized for the identification of mirror repeats. Results: We identified 53 mirror repeats within ced-9 gene of C. elegans, and these identified mirror repeats were explored among the genome of other organisms such as Caenorhabditis vulgaris, Xenopus tropicalis, and Drosophila melanogaster. Conclusions: At the first time, we have characterized mirror repeats within ced-9 gene of C. elegans. We identified some homopurine- and homopyrimidine-rich sequences that have the potential to form unusual DNA structures.http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2023;volume=7;issue=2;spage=253;epage=259;aulast=Dhankharcaenorhabditis elegansh-dnamirror repeatnon-b-dna tool |
| spellingShingle | Mamta Dhankhar Deepti Yadav Vikash Bhardwaj In silico Evaluation of mirror repeats within ced-9 Gene of Caenorhabditis elegans Biomedical and Biotechnology Research Journal caenorhabditis elegans h-dna mirror repeat non-b-dna tool |
| title | In silico Evaluation of mirror repeats within ced-9 Gene of Caenorhabditis elegans |
| title_full | In silico Evaluation of mirror repeats within ced-9 Gene of Caenorhabditis elegans |
| title_fullStr | In silico Evaluation of mirror repeats within ced-9 Gene of Caenorhabditis elegans |
| title_full_unstemmed | In silico Evaluation of mirror repeats within ced-9 Gene of Caenorhabditis elegans |
| title_short | In silico Evaluation of mirror repeats within ced-9 Gene of Caenorhabditis elegans |
| title_sort | in silico evaluation of mirror repeats within ced 9 gene of caenorhabditis elegans |
| topic | caenorhabditis elegans h-dna mirror repeat non-b-dna tool |
| url | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2023;volume=7;issue=2;spage=253;epage=259;aulast=Dhankhar |
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