Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin

Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin

The implementation of three-dimensional tissue engineering concurrently with stem cell technology holds great promise for in vitro research in pharmacology and toxicology and modeling cardiac diseases, particularly for rare genetic and pediatric diseases for which animal models, immortal cell lines,...

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Bibliographic Details
Main Authors: Veniamin Y. Sidorov, Tatiana N. Sidorova, Philip C. Samson, Ronald S. Reiserer, Clayton M. Britt, M. Diana Neely, Kevin C. Ess, John P. Wikswo
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Bioengineering
Subjects:
tuberous sclerosis complex
hiPSC
mTOR
rapamycin
I-Wire cardiac construct
heart-on-a-chip
Online Access:https://www.mdpi.com/2306-5354/11/3/234

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